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Creator |
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| authors |
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d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44104 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 66779 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
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d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44081 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44096 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44111 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 55063 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_20 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_3 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44107 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_5 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44108 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_5 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_3 |
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| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44093 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
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| authors |
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| authors |
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| authors |
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d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44077 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44110 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 45885 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44113 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44106 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_4 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 45886 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_4 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44080 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 60688 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44084 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44090 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_3 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_4 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44101 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44079 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44089 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_7 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44094 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44095 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44097 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44082 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44105 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 45883 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44085 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44092 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_2 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 62490 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_4 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44109 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44088 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44100 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44098 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44112 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44102 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_3 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_6 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44087 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44091 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 55220 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44078 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_1 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 45884 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44083 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44086 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44103 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 67442 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_4 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 67945 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_3 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 69484 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_3 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 71160 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| authors |
_5 |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
jobTitle |
Honorary Associate |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
research overview |
<p><strong>The aetiology and treatment of Cerebral Amyloid Angiopathy </strong></p><p>One
of my primary research interests is the pathogenesis of Alzheimer’s disease
(AD), with particular focus on cerebral amyloid angiopathy (CAA), the deposition of
toxicß-amyloid (Aß) aggregates that accumulate in the walls of blood vessels
in the elderly brain. These vascular Aβ deposits cause vasoconstriction,
inhibit angiogenesis and induce endothelial and smooth muscle cell death, leading
to microhaemorrhage, stroke and dementia. Despite affecting nearly 30% of all
elderly individuals and over 90% of AD patients, this phenomenon is significantly
under-researched. Moreover, there are no currently approved therapies for the
treatment or prevention of CAA. </p><p>My goal is to determine key elements that
underlie cerebrovascular ageing and the development of CAA and to uncover physiologic
and therapeutic mechanisms by which it can be prevented and treated. </p><p><strong>Impact
of maternal obesity on the health of the offspring across the lifecourse</strong></p><p>I
am also interested in the long-term impact of perinatal health and of maternal
obesity in particular, on brain function in ageing and the risk of developing AD.
Increasing evidence supports a role of maternal obesity in influencing the health
of the offpsring, including a predisposition to obesity, metabolic disoders and premature
death. However, much less is known about how this affect brain ageing and cogntive
function. My goal is detemine how maternal obesity affects cognitive function in the
aged offpsring and the epigenetic and cellular mechanisms that underlie these effects.</p> |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
hasMembership |
faculty-of-science,-technology,-engineering&mathematics |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
biography |
<p>I completed my Ph.D. in Neurological Sciences at McGill University in 2006, studying
the role of the insulin-like growth factor-II (IGF-II/M6P) receptor in the regulation
of cholinergic neurons. </p><p>I then undertook a post-doctoral fellowship at
the Tanz Centre for Neurodegenerative Diseases at the University of Toronto, where
I conducted experiments using small molecules to prevent the accumulation of theβ-amyloid
(Aβ) peptide that occurs in the Alzheimer’s disease brain.<br /><br />I
joined the Faculty of Medicine at the University of Southampton in 2009 to study how
the blood vessels of the brain change with age and how this impacts on the development
of Alzheimer’s disease. </p><p>In 2014, I joined the Dept. of Life, Health
and Chemical Sciences at the Open University as a Lecturer in Neuroscience to continue
working on the vasculature of the ageing brain and how this is impacted by risk factors
for Alzheimer's disease and Cerebral Amyloid Angiopathy.<br /><br />B.Sc., Neuroscience,
University of Alberta, Edmonton, Canada (2000)<br />Ph.D., Neurological Sciences,
McGill University, Montreal, Canada (2006)</p> |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
holder_of |
VisitingFormalAcademic |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
type |
Person |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
label |
Dr Cheryl Hawkes |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
account |
ch25365 |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
familyName |
Hawkes |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
Given name |
Cheryl |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
Given name |
C. |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
Given name |
C. A. |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
Given name |
Cheryl A |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
Given name |
Cheryl A. |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
sha1sum of a personal mailbox URI name |
c2953dc36b6744b5a47bbf8d20ff499df2a17371 |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
name |
Cheryl Hawkes |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
name |
C. A. Hawkes |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
name |
C. Hawkes |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
name |
Cheryl A Hawkes |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
name |
Cheryl A. Hawkes |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
title |
Dr |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
work info homepage |
ch25365 |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
Description |
<p>I completed my Ph.D. in Neurological Sciences at McGill University in 2006, studying
the role of the insulin-like growth factor-II (IGF-II/M6P) receptor in the regulation
of cholinergic neurons. </p><p>I then undertook a post-doctoral fellowship at
the Tanz Centre for Neurodegenerative Diseases at the University of Toronto, where
I conducted experiments using small molecules to prevent the accumulation of theβ-amyloid
(Aβ) peptide that occurs in the Alzheimer’s disease brain.<br /><br />I
joined the Faculty of Medicine at the University of Southampton in 2009 to study how
the blood vessels of the brain change with age and how this impacts on the development
of Alzheimer’s disease. </p><p>In 2014, I joined the Dept. of Life, Health
and Chemical Sciences at the Open University as a Lecturer in Neuroscience to continue
working on the vasculature of the ageing brain and how this is impacted by risk factors
for Alzheimer's disease and Cerebral Amyloid Angiopathy.<br /><br />B.Sc., Neuroscience,
University of Alberta, Edmonton, Canada (2000)<br />Ph.D., Neurological Sciences,
McGill University, Montreal, Canada (2006)</p> |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
in dataset |
oro |
| d64a4c8b9d6fb32d441f1cd9c453d93b |
in dataset |
profiles |