| 44098 |
Creator |
d64a4c8b9d6fb32d441f1cd9c453d93b |
| 44098 |
Creator |
ext-33cce9c3d513a2d864fc0dd0858432ed |
| 44098 |
Date |
2008 |
| 44098 |
Is Part Of |
repository |
| 44098 |
Is Part Of |
p17406773 |
| 44098 |
abstract |
The success of active and passive anti-Aβ immunotherapies in both preventing and clearing
parenchymal amyloid in transgenic mouse models, led to the initiation of an active
anti-Aβ vaccination trial in human patients with mild-to-moderate AD, which was prematurely
halted in 2002 because of inflammatory complications. Since then, Aβ immunotherapy
strategies have been refined to produce antibodies that specifically target neurotoxic
amyloid species without eliciting adverse side effects. More than seven major clinical
trials are currently ongoing to test the safety and efficacy of the new generation
of active and passive anti-Aβ vaccines. Results from these trials will provide valuable
information about the effectiveness of immunotherapy in slowing and/or reversing cognitive
impairments and will provide direction for the future of antiAβ immunization as an
interventional or prophylactic clinical tool. |
| 44098 |
authorList |
authors |
| 44098 |
issue |
3 |
| 44098 |
status |
peerReviewed |
| 44098 |
volume |
5 |
| 44098 |
type |
AcademicArticle |
| 44098 |
type |
Article |
| 44098 |
label |
Hawkes, Cheryl A. and McLaurin, JoAnne (2008). Clinical immunotherapy trials
in Alzheimer's disease. Drug Discovery Today: Therapeutic Strategies, 5(3) pp. 177–183.
|
| 44098 |
label |
Hawkes, Cheryl A. and McLaurin, JoAnne (2008). Clinical immunotherapy trials in
Alzheimer's disease. Drug Discovery Today: Therapeutic Strategies, 5(3) pp. 177–183. |
| 44098 |
Title |
Clinical immunotherapy trials in Alzheimer's disease |
| 44098 |
in dataset |
oro |