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jobTitle |
Senior Lecturer in Neuroscience |
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research overview |
<span class="GramE"><font size="2"><div><strong><span style="FONT-SIZE: 10pt"><div><strong><span
style="FONT-SIZE: 11pt">Functional neural circuits in the prefrontal cortex</span></strong></div></span></strong></div><div><strong><span
style="FONT-SIZE: 10pt"></span></strong></div></font></span><span class="GramE"><div><font
size="2">The prefrontal areas of the mammalian brain are involved in‘higher
order brain functions’ such as cognition and goal-directed behaviours. Whilst
the prefrontal cortex is known to be selectively affected by devastating neurological
and psychological disorders (including Alzheimer’s disease, schizophrenia and
depression), the neuroanatomical correlates are poorly defined. My main research interest
concerns the structural and functional connectivity of the prefrontal cortex<span
style="FONT-SIZE: 10pt">and related limbic regions</span></font><span style="FONT-SIZE:
10pt">in a variety of mammalian species, including man.</span></div><div><span style="FONT-SIZE:
10pt">The ambitious research investigates the interconnectivity of neural networks
in specific areas of the prefrontal cortex at a number of correlated levels of analysis
ranging from neurochemically identified synaptic connections to functionally characterized
neural circuits– not only as a result of normal development but alsoin specific
behavioural paradigms.</span></div><div><span style="FONT-SIZE: 10pt">The overall
remit of the research is to identify key neural circuits in the prefrontal cortex
that are specifically compromised in human brain disorders with the aim of identifying
possible pharmacotherapeutic interventions.</span></div><div><span style="FONT-SIZE:
10pt"></span></div><div><span style="FONT-SIZE: 10pt"></span></div><div><span style="FONT-SIZE:
10pt"></span></div><div><span style="FONT-SIZE: 10pt"></span></div><div><span style="FONT-SIZE:
10pt"></span></div><div><span style="FONT-SIZE: 10pt"></span></div><div><span style="FONT-SIZE:
10pt"></span></div><div><span style="FONT-SIZE: 10pt"></span></div><div><span style="FONT-SIZE:
10pt">Member of the Editorial Review Board for Brain Research.</span></div><div><span
style="FONT-SIZE: 10pt">Reviewer for specialist scientific journals: Brain Research,
Neuroscience, Journal of Comparative Neurology, Neural Structure and Function, Cerebral
Cortex, Journal of Neuroscience and Hippocampus.</span></div><div><span style="FONT-SIZE:
10pt">Reviewer for grant awarding bodies: National Science Foundation (USA), MRC (UK),
Wellcome Trust and Austrian Science Fund.</span></div><div><span style="FONT-SIZE:
10pt"></span></div></span><font size="2"><font size="+0"><div style="MARGIN-LEFT:
36.75pt; LINE-HEIGHT: 150%"><span style="FONT-SIZE: 10pt; LINE-HEIGHT: 150%"><div><span
style="FONT-SIZE: 10pt">Models of neuronal and synaptic organisation of the mammalian
prefrontal cortex</span></div><div><span style="FONT-SIZE: 10pt">Efferent synaptic
connectivity of projection neurons in prefrontal cortex.</span></div><div><span style="FONT-SIZE:
10pt">Amygdala input to corticospinal neurons in prelimbic cortex.</span></div><div><span
style="FONT-SIZE: 10pt">Layer 1‘Thorn cells’ in prefrontal cortex.</span></div><div><span
style="FONT-SIZE: 10pt">Subpopulations of corticospinal neurons in prelimbic cortex.</span></div><div><span
style="FONT-SIZE: 10pt">Morphology and three-dimensional synaptic connectivity of
hilar‘Mossy-cells’.</span></div><div><span style="FONT-SIZE: 10pt">Quantitative
definition of infralimbic cortical innervation of the periaqueductal grey.</span></div><div><span
style="FONT-SIZE: 10pt">Ultrastructural effects of beta-amyloid on the prelimbic cortex
and hippocampus.</span></div><div><span style="FONT-SIZE: 10pt">Projections from rat
infralimbic cortex (area 25) to catecholaminergic brain stem neurons.</span></div><div> </div><div><span
style="FONT-WEIGHT: normal; FONT-SIZE: 10pt"><strong>Collaborations</strong></span></div><div><span
style="FONT-SIZE: 10pt">Promemoria EU Framework 6 Integrated Research Consortium:</span></div><div><span
style="FONT-SIZE: 10pt">Professor Carmen Sandi, Mind-Brain Institute, Lausanne. Switzerland.</span></div><div><span
style="FONT-SIZE: 10pt">Professor Marina Lynch, Neuroscience Institute, Trinity College,
Dublin, Ireland.</span></div><div><span style="FONT-SIZE: 10pt">Professor Elizabeth
Bock, Pannum Institute, University of Copenhagen, Copenhagen, Denmark.</span></div><div><span
style="FONT-SIZE: 10pt">Professor Gal Richter-Levin, Dept. of Physiology, Haifa University,
Haifa, Israel.</span></div><div><span style="FONT-SIZE: 10pt">Professor Serge Karnup,
Dept of Physiology and Pharmacology, State University of New York, New York.</span></div><div><span
style="FONT-SIZE: 10pt">Professor Victor Popov, Institute of Cell Biophysics, Russian
Academy of Sciences, Puschino, Russia.</span></div><div><span style="FONT-SIZE: 10pt">Professor
Wolfram Schultz, Dept of Anatomy, University of Cambridge, Cambridge, England</span></div><div><span
style="FONT-SIZE: 10pt">Professor Edmund Rolls, Dept. Experimental Psychology, University
of Oxford, Oxford, England.</span></div><div><span style="FONT-SIZE: 10pt"></span></div><div><span
style="FONT-SIZE: 10pt"><div><span style="FONT-SIZE: 10pt">See also:<a href="http://www.open.ac.uk/personalpages/p.l.gabbott/">http://www.open.ac.uk/personalpages/p.l.gabbott/</a></span></div></span></div></span></div></font></font> |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
hasMembership |
faculty-of-science |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
biography |
<div><div><div><span style="FONT-SIZE: 10pt">Paul Gabbott has an honours degree in
Physics and Biological Sciences from Keele University and a PhD in Quantitative Neuroanantomy
from The Open University. Before returning to the Open University in 2003, he undertook
neuroanatomical research at Oxford University where he was initially a Beit Memorial
Research Fellow and then a Wellcome Trust Research Career Development Fellow in the
University Department of Pharmacology. Latterly he was an MRC Research Fellow in the
Interdisciplinary Research Centre in the Department of Experimental Psychology at
Oxford.</span></div><div><span style="FONT-SIZE: 10pt"></span></div><div><span style="FONT-SIZE:
10pt">See also:<a href="http://www.open.ac.uk/personalpages/p.l.gabbott/">http://www.open.ac.uk/personalpages/p.l.gabbott/</a></span></div></div></div> |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
holder_of |
CentralAcademicStaff |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
type |
Person |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
label |
Dr Paul Leonard Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
account |
plg53 |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
familyName |
Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
Paul |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
P. |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
P. L. |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
P.L. |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
P.L.A. |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
P.L.G. |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
Paul L. |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Given name |
Paul L.A. |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
homepage |
http://intranet.open.ac.uk/personalpages/p.l.gabbott/ |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
sha1sum of a personal mailbox URI name |
f0168386f8fdfffeb042e65fe94aa0e9bd731d66 |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
Paul Leonard Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
P. Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
P. L. Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
P.L. Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
P.L.A. Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
P.L.G. Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
Paul Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
Paul L. Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
name |
Paul L.A. Gabbott |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
title |
Dr |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
work info homepage |
plg53 |
| aab44b3dcdeb886773890fd6ebe6c4a7 |
Description |
<div><div><div><span style="FONT-SIZE: 10pt">Paul Gabbott has an honours degree in
Physics and Biological Sciences from Keele University and a PhD in Quantitative Neuroanantomy
from The Open University. Before returning to the Open University in 2003, he undertook
neuroanatomical research at Oxford University where he was initially a Beit Memorial
Research Fellow and then a Wellcome Trust Research Career Development Fellow in the
University Department of Pharmacology. Latterly he was an MRC Research Fellow in the
Interdisciplinary Research Centre in the Department of Experimental Psychology at
Oxford.</span></div><div><span style="FONT-SIZE: 10pt"></span></div><div><span style="FONT-SIZE:
10pt">See also:<a href="http://www.open.ac.uk/personalpages/p.l.gabbott/">http://www.open.ac.uk/personalpages/p.l.gabbott/</a></span></div></div></div> |
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