| 10367 |
Creator |
4de854f542f9d6b1f31bc23c95154aa0 |
| 10367 |
Creator |
7886d8a8c9204366c84d0d91a5a53953 |
| 10367 |
Creator |
aab44b3dcdeb886773890fd6ebe6c4a7 |
| 10367 |
Creator |
0db3bf16f8a5801f2fc91f3b6d2c5978 |
| 10367 |
Creator |
a49cd65f994f44f9567f65920769d193 |
| 10367 |
Creator |
cb7684be22723b3c4fd296568682adef |
| 10367 |
Creator |
ext-380c65005ef02d77c9f6c2fe1ccd4ba8 |
| 10367 |
Creator |
ext-56be89f3ed4b4b8c4b4a0bb17c35e9ee |
| 10367 |
Creator |
ext-9311a0400fafde61d01123850e960e21 |
| 10367 |
Creator |
ext-ee3a85c0970e31b593b868b7e2017b7b |
| 10367 |
Date |
2008 |
| 10367 |
Is Part Of |
p0953816X |
| 10367 |
Is Part Of |
repository |
| 10367 |
abstract |
The FGL peptide is a neural cell adhesion molecule (NCAM) mimetic comprising a 15-amino-acid-long
sequence of the FG loop region of the second fibronectin type III module of NCAM.
It corresponds to the binding site of NCAM for the fibroblast growth factor receptor
1. FGL improves cognitive function through enhancement of synaptic function. We examined
the effect of FGL on synaptic and dendritic structure in the brains of aged (22-month-old)
rats that were injected subcutaneously (8 mg /kg) at 2-day intervals until 19 days
after the start of the experiment. Animals were perfused with fixative, brains removed
and coronal sections cut at 50 lm. The hippocampal volume was measured, tissue embedded
and ultrathin sections viewed in a JEOL 1010 electron microscope. Analyses were made
of synaptic and dendritic parameters following three-dimensional reconstruction via
images from a series of 100 serial ultrathin sections. FGL affected neither hippocampal
volume nor spine or synaptic density in the middle molecular layer of the dentate
gyrus. However, it increased the ratio of mushroom to thin spines, number of multivesicular
bodies and also increased the frequency of appearance of coated pits. Three-dimensional
analysis showed a significant decrease in both post-synaptic density and apposition
zone curvature of mushroom spines following FGL treatment, whereas for thin spines
the convexity of the apposition zone increased. These data indicate that FGL induces
large changes in the fine structure of synapses and dendritic spines in hippocampus
of aged rats, complementing data showing its effect on cognitive processes. |
| 10367 |
authorList |
authors |
| 10367 |
issue |
2 |
| 10367 |
status |
peerReviewed |
| 10367 |
volume |
27 |
| 10367 |
type |
AcademicArticle |
| 10367 |
type |
Article |
| 10367 |
label |
Popov, Victor I. ; Medvedev, Nikolay I. ; Kraev, Igor V. ; Gabbott, Paul L. ; Davies,
Heather A. ; Lynch, Marina; Cowley, Thelma R.; Berezin, Vladmir; Bock, Elisabeth and
Stewart, Michael (2008). A cell adhesion molecule mimetic, FGL peptide, induces
alterations in synapse and dendritic spine structure in the dentate gyrus of aged
rats: a three-dimensional ultrastructural study. European Journal of Neuroscience,
27(2) pp. 301–314. |
| 10367 |
label |
Popov, Victor I. ; Medvedev, Nikolay I. ; Kraev, Igor V. ; Gabbott, Paul L. ; Davies,
Heather A. ; Lynch, Marina; Cowley, Thelma R.; Berezin, Vladmir; Bock, Elisabeth and
Stewart, Michael (2008). A cell adhesion molecule mimetic, FGL peptide, induces
alterations in synapse and dendritic spine structure in the dentate gyrus of aged
rats: a three-dimensional ultrastructural study. European Journal of Neuroscience,
27(2) pp. 301–314. |
| 10367 |
Title |
A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and
dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural
study |
| 10367 |
in dataset |
oro |