subject predicate object context
71812 Creator c3baa1aae2495d9fcf383c433b46bfe0
71812 Creator ext-2c8fc13978070e5de416c72198fe22cd
71812 Creator ext-52897e189afaaf748a9872e42f20b4c9
71812 Creator ext-7c548ac1e6fdebe3b8d9b8b76f296758
71812 Creator ext-9fe53eb0bc1b1b11ea63dc8e78880851
71812 Creator ext-fb7e57665b04b56075fcc9eee3e2f093
71812 Date 2020
71812 Is Part Of repository
71812 Is Part Of p19961944
71812 abstract Infections are common complications in joint replacement surgeries. Eradicated infections can lead to implant failure. In this paper, analogues of the peptide KR-12 derived from the human cathelicidin LL-37 were designed, synthesised, and characterised. The designed antimicrobial peptides (AMPs) were attached to the surface of a titanium alloy, Ti6Al4V, by conjugation to a polydopamine linking substrate. The topography of the polydopamine coating was evaluated by electron microscopy and coating thickness measurements were performed with ellipsometry and Atomic Force Microscopy (AFM). The subsequently attached peptide stability was investigated with release profile studies in simulated body fluid, using both fluorescence imaging and High-Performance Liquid Chromatography (HPLC). Finally, the hydrophobicity of the coating was characterised by water contact angle measurements. The designed AMPs were shown to provide long-term bonding to the polydopamine-coated Ti6Al4V surfaces.
71812 authorList authors
71812 issue 17
71812 status published
71812 status peerReviewed
71812 uri http://data.open.ac.uk/oro/document/1205186
71812 uri http://data.open.ac.uk/oro/document/1205187
71812 uri http://data.open.ac.uk/oro/document/1205188
71812 uri http://data.open.ac.uk/oro/document/1205189
71812 uri http://data.open.ac.uk/oro/document/1205190
71812 uri http://data.open.ac.uk/oro/document/1205191
71812 uri http://data.open.ac.uk/oro/document/1206921
71812 volume 13
71812 type AcademicArticle
71812 type Article
71812 label TrzciƄska, Zuzanna; Bruggeman, Marc; Ijakipour, Hanieh; Hodges, Nikolas J.; Bowen, James and Stamboulis, Artemis (2020). Polydopamine Linking Substrate for AMPs: Characterisation and Stability on Ti6Al4V. Materials, 13(17), article no. e3714.
71812 Publisher ext-0e8d92de9fd14082663dc2f585fd1d29
71812 Title Polydopamine Linking Substrate for AMPs: Characterisation and Stability on Ti6Al4V
71812 in dataset oro