71812 |
Creator |
c3baa1aae2495d9fcf383c433b46bfe0 |
71812 |
Creator |
ext-2c8fc13978070e5de416c72198fe22cd |
71812 |
Creator |
ext-52897e189afaaf748a9872e42f20b4c9 |
71812 |
Creator |
ext-7c548ac1e6fdebe3b8d9b8b76f296758 |
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Creator |
ext-9fe53eb0bc1b1b11ea63dc8e78880851 |
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Creator |
ext-fb7e57665b04b56075fcc9eee3e2f093 |
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Date |
2020 |
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Is Part Of |
repository |
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Is Part Of |
p19961944 |
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abstract |
Infections are common complications in joint replacement surgeries. Eradicated infections
can lead to implant failure. In this paper, analogues of the peptide KR-12 derived
from the human cathelicidin LL-37 were designed, synthesised, and characterised. The
designed antimicrobial peptides (AMPs) were attached to the surface of a titanium
alloy, Ti6Al4V, by conjugation to a polydopamine linking substrate. The topography
of the polydopamine coating was evaluated by electron microscopy and coating thickness
measurements were performed with ellipsometry and Atomic Force Microscopy (AFM). The
subsequently attached peptide stability was investigated with release profile studies
in simulated body fluid, using both fluorescence imaging and High-Performance Liquid
Chromatography (HPLC). Finally, the hydrophobicity of the coating was characterised
by water contact angle measurements. The designed AMPs were shown to provide long-term
bonding to the polydopamine-coated Ti6Al4V surfaces. |
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authorList |
authors |
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issue |
17 |
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status |
published |
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status |
peerReviewed |
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uri |
http://data.open.ac.uk/oro/document/1205186 |
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uri |
http://data.open.ac.uk/oro/document/1205187 |
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uri |
http://data.open.ac.uk/oro/document/1205188 |
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uri |
http://data.open.ac.uk/oro/document/1205189 |
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uri |
http://data.open.ac.uk/oro/document/1205190 |
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uri |
http://data.open.ac.uk/oro/document/1205191 |
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uri |
http://data.open.ac.uk/oro/document/1206921 |
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volume |
13 |
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type |
AcademicArticle |
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type |
Article |
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label |
TrzciĆska, Zuzanna; Bruggeman, Marc; Ijakipour, Hanieh; Hodges, Nikolas J.; Bowen,
James and Stamboulis, Artemis (2020). Polydopamine Linking Substrate for AMPs: Characterisation
and Stability on Ti6Al4V. Materials, 13(17), article no. e3714. |
71812 |
Publisher |
ext-0e8d92de9fd14082663dc2f585fd1d29 |
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Title |
Polydopamine Linking Substrate for AMPs: Characterisation and Stability on Ti6Al4V |
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in dataset |
oro |