| 46018 |
Creator |
c3baa1aae2495d9fcf383c433b46bfe0 |
| 46018 |
Creator |
ext-27d3dae61d0484c7f897aa8a7c39fbc0 |
| 46018 |
Creator |
ext-5bbac832fc636067cbc0d70c1e420b54 |
| 46018 |
Creator |
ext-cfba6d6e561240b36fb0b3d980d47235 |
| 46018 |
Creator |
ext-d032a541f9d9a09b0636c3aa2b0027d0 |
| 46018 |
Creator |
ext-f5ca89514f9a3167aa7eeef8819129df |
| 46018 |
Creator |
ext-f71632432dd4994ef3693f7f9487cb67 |
| 46018 |
Date |
2015-09-06 |
| 46018 |
Is Part Of |
repository |
| 46018 |
abstract |
We successfully demonstrate the synthesis of polymer microspheres using a single electrospray
source, and show their physical characterisation. Electrospray has proven to be a
versatile method to manufacture particles, giving tight control over size with quasi-monodisperse
size distributions. It is a liquid atomisation technique that generates a monodisperse
population of highly charged liquid droplets over a broad size range (nanometres to
tens of microns). The droplets contain liquid precursors for the in-flight synthesis
of particles, and control over the trajectory of these droplets can be precisely manipulated
with the use of electric fields to drive them to a grounded substrate. This study
reports a method to synthesize poly(lactic-co-glycolic) acid (PLGA) microspheres using
the electrospray and thermally induced phase separation (TIPS) techniques, followed
by subsequent freeze-drying, for particle production. These microspheres are of interest
as vehicles for controlled drug release systems. |
| 46018 |
authorList |
authors |
| 46018 |
presentedAt |
ext-0db2fe24c2b84b08fe373091ad1fd9e8 |
| 46018 |
status |
peerReviewed |
| 46018 |
uri |
http://data.open.ac.uk/oro/document/434432 |
| 46018 |
uri |
http://data.open.ac.uk/oro/document/434437 |
| 46018 |
uri |
http://data.open.ac.uk/oro/document/434438 |
| 46018 |
uri |
http://data.open.ac.uk/oro/document/434439 |
| 46018 |
uri |
http://data.open.ac.uk/oro/document/434440 |
| 46018 |
uri |
http://data.open.ac.uk/oro/document/434441 |
| 46018 |
uri |
http://data.open.ac.uk/oro/document/434680 |
| 46018 |
type |
AcademicArticle |
| 46018 |
type |
Article |
| 46018 |
label |
Malik, S. A.; Ng, W. H.; Bowen, J. ; Tang, J.; Gomez, A.; Kenyon, A. J. and Day,
R. M. (2015). Electrospray synthesis of PLGA TIPS microspheres. In: European Aerosol
Conference, 6-11 Sep 2015, Milan, Italy. |
| 46018 |
label |
Malik, S. A.; Ng, W. H.; Bowen, J. ; Tang, J.; Gomez, A.; Kenyon, A. J. and Day, R.
M. (2015). Electrospray synthesis of PLGA TIPS microspheres. In: European Aerosol
Conference, 6-11 Sep 2015, Milan, Italy. |
| 46018 |
Title |
Electrospray synthesis of PLGA TIPS microspheres |
| 46018 |
in dataset |
oro |