| 45741 |
Creator |
c3baa1aae2495d9fcf383c433b46bfe0 |
| 45741 |
Creator |
ext-cba1cfcb83c0c53363d5ee22f902d34d |
| 45741 |
Creator |
ext-251c20d34cf3924322d349a08dc286dc |
| 45741 |
Date |
2016-01-30 |
| 45741 |
Is Part Of |
repository |
| 45741 |
Is Part Of |
p15206017 |
| 45741 |
abstract |
The aim of this study was to develop and characterise an intranasal delivery system
for amantadine (AMT). Optimal formulations (F) consisted of a thermosensitive polymer
Pluronic® 127 (P127) and either carboxy methyl cellulose (CMC) or chitosan (CS) which
demonstrated gel-transition at nasal cavity temperatures (34 °C ± 1 °C). Rheologically,
the loss tangent (Tan δ) confirmed a three-stage gelation phenomena at 34 °C ± 1 °C
and non-Newtonian behaviour. Storage of FCMC and FCS at 4 °C for 8 weeks resulted
in repeatable release profiles at 34 °C when sampled, with a Fickian mechanism earlier
on but moving towards anomalous transport by week 8. Polymers (P127, CMC and CS)
demonstrated no significant cellular toxicity to human nasal epithelial cells up to
4 mg/mL and up to 1 mM for AMT (IC<sub>50</sub>: 4.5 mM ± 0.05 mM). FCMC and FCS demonstrated
slower release across an <i>in-vitro</i> human nasal airway model (43-44 % vs 79 %
± 4.58 % for AMT). Using a human nasal cast model, deposition into the olfactory
regions (potential nose-to-brain) was demonstrated upon nozzle insertion (5 mm) whereas
tilting of the head forward (15°) resulted in greater deposition in the bulk of the
nasal cavity. |
| 45741 |
authorList |
authors |
| 45741 |
issue |
3 |
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status |
peerReviewed |
| 45741 |
uri |
http://data.open.ac.uk/oro/document/423422 |
| 45741 |
uri |
http://data.open.ac.uk/oro/document/423428 |
| 45741 |
uri |
http://data.open.ac.uk/oro/document/423429 |
| 45741 |
uri |
http://data.open.ac.uk/oro/document/423430 |
| 45741 |
uri |
http://data.open.ac.uk/oro/document/423431 |
| 45741 |
uri |
http://data.open.ac.uk/oro/document/423432 |
| 45741 |
uri |
http://data.open.ac.uk/oro/document/424096 |
| 45741 |
volume |
105 |
| 45741 |
type |
AcademicArticle |
| 45741 |
type |
Article |
| 45741 |
label |
Lungare, Shital; Bowen, James and Badhan, Raj (2016). Development and Evaluation
of a Novel Intranasal Spray for the Delivery of Amantadine. Journal of Pharmaceutical
Sciences, 105(3) pp. 1209–1220. |
| 45741 |
label |
Lungare, Shital; Bowen, James and Badhan, Raj (2016). Development and Evaluation
of a Novel Intranasal Spray for the Delivery of Amantadine. Journal of Pharmaceutical
Sciences, 105(3) pp. 1209–1220. |
| 45741 |
Title |
Development and Evaluation of a Novel Intranasal Spray for the Delivery of Amantadine |
| 45741 |
in dataset |
oro |