| 44816 |
Creator |
c3baa1aae2495d9fcf383c433b46bfe0 |
| 44816 |
Creator |
ext-042d0f1baf3f14a6cfeced7d7c726689 |
| 44816 |
Creator |
ext-5c665643af5db900a8aff4f66ee80a00 |
| 44816 |
Creator |
ext-8ff9b818d36331f734b27efcd08bc483 |
| 44816 |
Creator |
ext-b51573b1f8f8058a86d11618487637ea |
| 44816 |
Creator |
ext-daf2b2d7f96f7062ebff9507903de9e3 |
| 44816 |
Date |
2015-11-10 |
| 44816 |
Is Part Of |
repository |
| 44816 |
Is Part Of |
p20452322 |
| 44816 |
abstract |
Mannitol is an essential excipient employed in orally disintegrating tablets due to
its high palatability. However its fundamental disadvantage is its fragmentation during
direct compression, producing mechanically weak tablets. The primary aim of this study
was to assess the fracture behaviour of crystalline mannitol in relation to the energy
input during direct compression, utilising ball milling as the method of energy input,
whilst assessing tablet characteristics of post-milled powders. Results indicated
that crystalline mannitol fractured at the hydrophilic (011) plane, as observed through
SEM, alongside a reduction in dispersive surface energy. Disintegration times of post-milled
tablets were reduced due to the exposure of the hydrophilic plane, whilst more robust
tablets were produced. This was shown through higher tablet hardness and increased
plastic deformation profiles of the post-milled powders, as observed with a lower
yield pressure through an out-of-die Heckel analysis. Evaluation of crystal state
using x-ray diffraction/differential scanning calorimetry showed that mannitol predominantly
retained the β-polymorph; however x-ray diffraction provided a novel method to calculate
energy input into the powders during ball milling. It can be concluded that particle
size reduction is a pragmatic strategy to overcome the current limitation of mannitol
fragmentation and provide improvements in tablet properties. |
| 44816 |
authorList |
authors |
| 44816 |
status |
peerReviewed |
| 44816 |
uri |
http://data.open.ac.uk/oro/document/373609 |
| 44816 |
uri |
http://data.open.ac.uk/oro/document/373614 |
| 44816 |
uri |
http://data.open.ac.uk/oro/document/373616 |
| 44816 |
uri |
http://data.open.ac.uk/oro/document/373617 |
| 44816 |
uri |
http://data.open.ac.uk/oro/document/373618 |
| 44816 |
uri |
http://data.open.ac.uk/oro/document/373659 |
| 44816 |
volume |
5 |
| 44816 |
type |
AcademicArticle |
| 44816 |
type |
Article |
| 44816 |
label |
Koner, Jasdip S.; Rajabi-Siahboomi, Ali; Bowen, James ; Perrie, Yvonne; Kirby,
Daniel and Mohammed, Afzal R. (2015). A holistic multi evidence approach to study
the fragmentation behaviour of crystalline mannitol. Scientific Reports, 5, article
no. 16352. |
| 44816 |
label |
Koner, Jasdip S.; Rajabi-Siahboomi, Ali; Bowen, James ; Perrie, Yvonne; Kirby, Daniel
and Mohammed, Afzal R. (2015). A holistic multi evidence approach to study the fragmentation
behaviour of crystalline mannitol. Scientific Reports, 5, article no. 16352. |
| 44816 |
Title |
A holistic multi evidence approach to study the fragmentation behaviour of crystalline
mannitol |
| 44816 |
in dataset |
oro |