| 43400 |
Creator |
c3baa1aae2495d9fcf383c433b46bfe0 |
| 43400 |
Creator |
ext-0b887b61ffe971421f7a34bd1266c2b1 |
| 43400 |
Creator |
ext-408b672ac75bb9a35174bfe16c00dc5a |
| 43400 |
Date |
2013-04-16 |
| 43400 |
Is Part Of |
repository |
| 43400 |
abstract |
Treatments for Parkinson’s disease face significant challenges in delivery to the
due to the presence of blood brain barrier (BBB). The aim of this study was to develop
and characterise an in-situ thermoresponsive polymer based gel system for possible
exploitation of the intranasal olfactory route where the BBB is absent. Reaching the
olfactory region in the nasal cavity and mucociliary clearance are the main hurdles
from formulation point of view. Thermo-sensitive and pH sensitive polymers seem to
be the answer to these problems. Formulation made with these polymers along with mucoadhesives
will be liquid at room temperature and will turn into a viscous gel when comes in
contact with the body either due to change in pH or temperature. We have successfully
prepared the gels using cold method using amantadine, with Pluronic F127 as a thermoreversible
polymer and carboxymethylcelluose (CMS) as a mucoadhesive polymer. Rheological characterisation
confirmed the sol-to-gel phenomenon at desired temperatures. CMC increased the gelation
temperature with increase in concentration, whereas amantadine lowered the gelation
temperature with increase in concentration. After preliminary studies, 16 % of Pluronic
F127 found to be a suitable concentration for the formulation to change from sol-to-gel
at ambient nasal temperatures. Molecular, gene expression and drug transport studies
using the nasal epithelial cell lines RPMI 2650 are also under investigation along
with the development of an in-vitro olfactory-epithelial cell culture model to study
axonal transport. Unlike the animal studies this model will be faster to use, efficient
and also better representation of human olfactory system. |
| 43400 |
authorList |
authors |
| 43400 |
presentedAt |
ext-a7ec633539d1998d2231ef690e4d17ef |
| 43400 |
status |
nonPeerReviewed |
| 43400 |
type |
AcademicArticle |
| 43400 |
type |
Article |
| 43400 |
label |
Lungare, Shital; Bowen, James and Badhan, Raj Kumar Singh (2013). Overcoming
Parkinson’s disease: direct nose-to-brain delivery of amantadine. In: UK & Ireland
Controlled Release Society Annual Symposium, 16 Apr 2013, Reading, UK. |
| 43400 |
label |
Lungare, Shital; Bowen, James and Badhan, Raj Kumar Singh (2013). Overcoming Parkinson’s
disease: direct nose-to-brain delivery of amantadine. In: UK & Ireland Controlled
Release Society Annual Symposium, 16 Apr 2013, Reading, UK. |
| 43400 |
Title |
Overcoming Parkinson’s disease: direct nose-to-brain delivery of amantadine |
| 43400 |
in dataset |
oro |