| 43150 |
Creator |
c3baa1aae2495d9fcf383c433b46bfe0 |
| 43150 |
Creator |
ext-4de12bf03d8dd4a39d425eb037fbb9ed |
| 43150 |
Creator |
ext-01fda8049cbd7da04c02893d11b07da2 |
| 43150 |
Creator |
ext-9f82a3dc0aec0d2eea98c05feddedafe |
| 43150 |
Creator |
ext-9ffed9c7c69b6f0104f2904653114b97 |
| 43150 |
Creator |
ext-a3971d46c988d3999269a6f647a6d28d |
| 43150 |
Creator |
ext-bea445af4ee4f1c2dc807ed37fdcb061 |
| 43150 |
Date |
2015-03 |
| 43150 |
Is Part Of |
repository |
| 43150 |
Is Part Of |
p09284931 |
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abstract |
Calcium phosphate coatings have been applied to the surface of metallic prostheses
to mediate hard and soft tissue attachment for more than 40 years. Most coatings are
formed of high purity hydroxyapatite, and coating methods are often designed to produce
highly crystalline surfaces. It is likely however, that coatings of lower crystallinity
can facilitate more rapid tissue attachment since the surface will exhibit a higher
specific surface area and will be considerably more reactive than a comparable highly
crystalline surface. Here we test this hypothesis by growing a population of MC3T3
osteoblast-like cells on the surface of two types of hip prosthesis with similar composition,
but with differing crystallinity. The surfaces with lower crystallinity facilitated
more rapid cell attachment and increased proliferation rate, despite having a less
heterogeneous surface topography. This work highlights that the influence of the crystallinity
of HA at the nano-scale is dominant over macroscale topography for cell adhesion and
growth. Furthermore, crystallinity could be easily adjusted by without compromising
coating purity. These findings could facilitate designing novel coated calcium phosphate
surfaces that more rapidly bond tissue following implantation. |
| 43150 |
authorList |
authors |
| 43150 |
issue |
1 |
| 43150 |
status |
peerReviewed |
| 43150 |
uri |
http://data.open.ac.uk/oro/document/332521 |
| 43150 |
uri |
http://data.open.ac.uk/oro/document/332529 |
| 43150 |
uri |
http://data.open.ac.uk/oro/document/332530 |
| 43150 |
uri |
http://data.open.ac.uk/oro/document/332531 |
| 43150 |
uri |
http://data.open.ac.uk/oro/document/332532 |
| 43150 |
uri |
http://data.open.ac.uk/oro/document/332542 |
| 43150 |
uri |
http://data.open.ac.uk/oro/document/332754 |
| 43150 |
volume |
48 |
| 43150 |
type |
AcademicArticle |
| 43150 |
type |
Article |
| 43150 |
label |
Smith, Alan M.; Paxton, Jennifer Z.; Hung, Yi-Pei; Hadley, Martin J.; Bowen, James
; Williams, Richard L. and Grover, Liam M. (2015). Nanoscale crystallinity modulates
cell proliferation on plasma sprayed surfaces. Materials Science and Engineering:
C, 48(1) pp. 5–10. |
| 43150 |
label |
Smith, Alan M.; Paxton, Jennifer Z.; Hung, Yi-Pei; Hadley, Martin J.; Bowen, James
; Williams, Richard L. and Grover, Liam M. (2015). Nanoscale crystallinity modulates
cell proliferation on plasma sprayed surfaces. Materials Science and Engineering:
C, 48(1) pp. 5–10. |
| 43150 |
Title |
Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces |
| 43150 |
in dataset |
oro |