Avian HBV RNA encapsidation signal epsilon
The Avian HBV RNA encapsidation signal epsilon (AHBV epsilon) is an RNA structure that is shown to facilitate encapsidation of the required for viral replication. There are two main classes of encapsidation signals in avian hepatitis B viruses - Duck hepatitis B virus (DHBV) and Heron hepatitis B virus (HHBV) like. DHBV is used as a model to understand human Hepatitis B virus. Although studies have shown that the HHBV epsilon has less pairing in the upper stem than DHBV, this pairing is not absolutely required for DHBV infection in ducks.
- Caption
- enPredicted secondary structure and sequence conservation of AHBV_epsilon
- Comment
- enThe Avian HBV RNA encapsidation signal epsilon (AHBV epsilon) is an RNA structure that is shown to facilitate encapsidation of the required for viral replication. There are two main classes of encapsidation signals in avian hepatitis B viruses - Duck hepatitis B virus (DHBV) and Heron hepatitis B virus (HHBV) like. DHBV is used as a model to understand human Hepatitis B virus. Although studies have shown that the HHBV epsilon has less pairing in the upper stem than DHBV, this pairing is not absolutely required for DHBV infection in ducks.
- Depiction
- Has abstract
- enThe Avian HBV RNA encapsidation signal epsilon (AHBV epsilon) is an RNA structure that is shown to facilitate encapsidation of the required for viral replication. There are two main classes of encapsidation signals in avian hepatitis B viruses - Duck hepatitis B virus (DHBV) and Heron hepatitis B virus (HHBV) like. DHBV is used as a model to understand human Hepatitis B virus. Although studies have shown that the HHBV epsilon has less pairing in the upper stem than DHBV, this pairing is not absolutely required for DHBV infection in ducks. DHBV epsilon consists of a stem structure, a bulge and an apical loop (Fig. 1). The RNA structure was determined by chemical probing, NMR analysis and by mutagenesis. HHBV epsilon also consists of a stem structure, a bulge and an apical loop (Fig. 2). The RNA structure has been determined by chemical probing and by mutagenesis. However, it has less base pairing in the upper stem than DHBV epsilon. Recent NMR analysis of both the HHBV and DHBV epsilon have shown that the apical loop to be capped by a stable well-structured UGUU tetraloop. In the Rfam database a single covariation model (AHBV_epsilon box right) best discriminates between the true instances of the element in sequence databases and background. The secondary structure diagram is a computer generated view of the structure with highly conserved bases shown in red. It includes the major elements shown in Figures 1 and 2.
- Hypernym
- Structure
- Id
- enRF01313
- Is primary topic of
- Avian HBV RNA encapsidation signal epsilon
- Label
- enAvian HBV RNA encapsidation signal epsilon
- Link from a Wikipage to another Wikipage
- Avian hepatitis B virus
- Category:Cis-regulatory RNA elements
- Category:Hepadnaviridae
- Cis-regulatory element
- Covariation model
- Duck hepatitis B virus
- Encapsidation
- File:DHBV epsilon.png
- File:HHBV epsilon.jpg
- HBV RNA encapsidation signal epsilon
- Hepatitis B virus
- Heron hepatitis B virus
- Mutagenesis
- NMR spectroscopy
- Nucleic acid secondary structure
- Pregenomic RNA
- Rfam
- RNA structure
- Secondary structure
- Sequence conservation
- Stem loop
- Tetraloop
- Viral replication
- Virus
- Name
- enAHBV_epsilon cis-regulatory RNA element
- enAvian HBV RNA encapsidation signal epsilon
- Rfam
- enRF01313
- RnaType
- Cis-regulatory element
- SameAs
- 4UKGU
- Avian HBV RNA encapsidation signal epsilon
- m.04lj191
- Q4828546
- Subject
- Category:Cis-regulatory RNA elements
- Category:Hepadnaviridae
- Symbol
- enAHBV_epsilon
- TaxDomain
- enViruses
- Thumbnail
- WasDerivedFrom
- Avian HBV RNA encapsidation signal epsilon?oldid=1122800621&ns=0
- WikiPageLength
- 4312
- Wikipage page ID
- 19325688
- Wikipage revision ID
- 1122800621
- WikiPageUsesTemplate
- Template:Cn
- Template:GO
- Template:Infobox rfam
- Template:Molecular-cell-biology-stub
- Template:Reflist
- Template:Rfam
- Template:Short description
- Template:SO
