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jobTitle |
Lecturer in Chemistry |
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research overview |
<p>Altered patterns of cellular carbohydrates are characteristic of many disease states.
Changes in both in the sugars displayed upon the surface of proteins and lipids and
the cytosolic free oligosaccharides released from cellular degradation pathways provide
insights into disease states as well factors influencing protein catabolism and cellular
metabolism. As such, changes in the distribution of such species can be used
as markers to reveal perturbations in cellular metabolic processes. These
markers have the potential to be used as diagnostics and for the purpose of understanding
the effects of perturbations in cellular processes resulting from outside interventions
such as drug treatments.</p><p>In addition to the detection of aberrant glycosylation
states, characterisation of interactions between glycans and carbohydrate binding
proteins has the potential to directly inform the development of the therapeutic agents.
As well as the identification of new interaction partners, the characterisation
of glycosylated proteins also represents a huge challenge for the pharmaceutical industry.
Many modern and emergent biopharmaceuticals and therapies are based upon monoclonal
antibodies and other protein structures which are heavily glycosylated.<strong> </strong>Modification of
the glycosylation states of such therapeutics impacts not only their efficacy but
also their immunogenicity; and glycan analysis, particularly the analysis of sialic
acid, is a regulatory requirement. As such, there is a burgeoning market for
tools to facilitate the accurate structural analysis of carbohydrate structures, as
it is imperative that analytical methods keep pace with the development of increasingly
complex therapeutic agents. </p><p>My research interests are broadly based upon
using chemical biology tools for the synthesis, structural characterisation and elucidation
of function of biologically relevant carbohydrates. My group work closely alongside
industrial companies in the fine chemical, biotechnological and pharmaceutical
industry as well as academic partners in the biomedical sciences. </p><h5>Grants
and Funding</h5><p><strong>A</strong><strong>ward: </strong>EPSRC First Grant
Scheme<strong>(2016)</strong></p><p><strong>Title of Project:</strong>Integrated workflows
for glycan analysis: tagging strategies to facilitate structural and functional characterisation
of carbohydrates - £100,802 </p><p><strong>Award:</strong> Royal
Society Research Grant 2016R1 <strong>(2016)</strong></p><p><strong>Title of
Project:</strong> Activity-based probes for glycosidases - covalent iminosugar
enzyme inhibitors bearing multifunctional tags for discovery and functional characterisation
of novel biocatalysts -£10,500</p><p><strong>Award: </strong>IBCarb
Summer Studentship <strong>(2016)</strong></p><p><strong>Title of Project: </strong>Integrated
workflows for carbohydrate analysis - development of methodology to facilitate functional
characterization and downstream use of complex carbohydrates isolated from natural
sources -£2,500</p><p><strong>Award:</strong>BBSRC Industrial Biotechnology
Catalyst (IBCAT) BB/M028879/1<strong>(2015)</strong></p><p><strong>Title of Project:</strong>Chemo-enzymatic
Production of Specialty Glycans -£364,803 (duration: 5 years) </p><p><strong>Award: </strong>IBCarb
BBSRC NIBB Business Interaction Voucher (IBCarb-BIV-0915-011)<strong>(2015)</strong></p><p><strong>Title
of Project:</strong>Industrial collaboration -£5,000</p><p><strong>Award:</strong>The
Royal Society of Chemistry Analytical Chemistry Trust Fund Summer Studentship<strong>(2015)</strong></p><p><strong>Title
of Project: </strong>Multi-functional labels for carbohydrate analysis -£1080</p><p><strong>Award:</strong>The
Biochemical Society– Eric Reid Fund for Methodology<strong>(2015)</strong></p><p><strong>Title
of Project: </strong>Characterising changes in carbohydrates - development of
methodology to facilitate characterisation of carbohydrate biomarkers -£950</p><p><em>Research
Group members</em></p><p><strong>Sarah Needs</strong>(PhD student) (Feb 2015 - ) Biochemical
basis of congenital glycosylation disorders</p><p><strong>Matthew Allen</strong>(PhD
student) (Oct 2016 - ) Development of tools for glycan analysis and quantitative sialic
acid glycomics</p><p><strong>Yahya Kahn</strong>(Feb 2017 - ) Preparation of recombinant<em>endo</em>-Lys-N
[EC 3.4.24.20] for glycoproteomics applications</p><p><strong>Yakub Kahn</strong>(Feb
2017 - ) Isolation and structural characterisation of<em>N-</em>glycans from basidiomycetes</p><p><strong>Dr
Emma Sery</strong>(Feb 2017 - ) Chemoenzymatic synthesis of specialty glycans</p><p><strong>Dr
Katarzyna Brzezicka</strong>(Feb 2017 - ) Integrated workflows for carbohydrate analysis</p><p><em>Former
Research Group members</em></p><p><strong>Søren Kaas</strong>(April 2015 -
April 2016) Design of novel radio-sensitizers</p><p><strong>Lucy McCanna</strong> (June
2015 - Dec 2015) Integrated workflows for carbohydrate biomarker characterisation</p><p><strong>Tony
Horne</strong>(Jun 2015 - Jun 2016) Fluorinated salicyl anilides as inhibitors
of mTORC1 signalling</p><p><strong>Abdullahi Adan</strong>(Feb 2016 - Jan 2017 ) Investigating
the effect of pathogenic and protective LRRK2 mutations on lysosomes</p><p><em>Co-supervision
responsibilities</em><strong> </strong></p><p>I have
responsibilities as a co-supervisor for a number of other students in the School,
providing expertise in chemical biology, cell biology and biochemical techniques.</p><p><strong>Sonia
Azeggagh</strong> (2016– present) Project: A“disease in a dish”
model for Parkinson’s disease. Supervisory team:<strong>Dr. Daniel Berwick</strong>(primary
supervisor) Dr. Sarah Allman, Dr. Kerry Murphy</p><p><strong>Tala Chehab</strong>(2014–
2018). Project: The role of calcium signalling in autophagy. Supervisory team:<strong>Dr.
Martin Bootman</strong>(primary supervisor), Dr. Katja Rietdorf, Dr. Sarah Allman</p><p> </p><p> </p> |
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hasMembership |
faculty-of-science |
| c3fb382d8485dab4cd59eb0e02f58fdb |
biography |
<p>I completed a M.Sci. in Chemistry in 2001 at King’s College, London.
Following my undergraduate degree I undertook a short period of study at the University
of Cambridge (Emmanuel College), working on small molecule natural product synthesis.
I then worked as a lecturer in science at a college of further education, teaching
applied sciences (chemistry, life sciences and health), the physical
science components of vocational qualifications and working cross-faculty
with curriculum access and learner support teams. After spending time teaching
in the FE sector, I took a position in the chemical industry as a research scientist
for ICI, developing polymer systems for commerical refinish products. </p><p>I
returned to university to read for a D.Phil. in Organic Chemistry at the University
of Oxford (Balliol College) under the supervision of Professor Ben Davis.
My doctoral studies focused on carbohydrate synthesis and functional studies of interactions
between synthetic oligosaccharides and carbohydrate binding proteins on microarray
platforms. Upon completion of my doctorate, I moved to the Biochemistry Department
at the University of Oxford as a post-doctoral research associate working within the
Oxford Institute of Glycobiology, alongside reading part-time for a MA in Education
with the The Open University (completed in 2013). I took up my current position
as a lecturer in Chemistry with The Open University in March 2014.</p><h5>Qualifications</h5><p><strong>2013</strong> M.A.
Education (distinction) (comprising: E891, E846, SEH806) - Faculty of Education and
Language Studies, The Open University </p><p><strong>2013</strong> Postgraduate Diploma
in Professional Studies in Education (distinction) - Faculty of Education and Language
Studies, The Open University</p><p><strong>2012</strong> Postgraduate
Certificate in Professional Studies in Education (distinction) - Faculty of Education
and Language Studies, The Open University</p><p><strong>2009</strong> D.Phil.
Organic Chemistry - Department of Chemistry, University of Oxford</p><p><em>“Chemical
Mapping - Chemoenzymatic synthesis of sialylated oligosaccharides as probes of innate
immunity”</em></p><p><strong>2003</strong> Certificate
of Postgraduate Study (Organic Chemistry) - Department of Chemistry, University of
Cambridge </p><p><strong>2003</strong> City and Guilds
7307 (Further and Adult Teacher's Certificate)</p><p><strong>2001</strong> M.Sci.
Chemistry (1st) - Department of Chemistry, King’s College London, University
of London</p> |
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Dr Sarah Ann Allman |
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Sarah A. |
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Sarah Ann |
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9624b19e43de6cb69f45fa714c9ad897f64b21ba |
| c3fb382d8485dab4cd59eb0e02f58fdb |
name |
Sarah Ann Allman |
| c3fb382d8485dab4cd59eb0e02f58fdb |
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Sarah Allman |
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Sarah A. Allman |
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Dr |
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work info homepage |
saa438 |
| c3fb382d8485dab4cd59eb0e02f58fdb |
Description |
<p>I completed a M.Sci. in Chemistry in 2001 at King’s College, London.
Following my undergraduate degree I undertook a short period of study at the University
of Cambridge (Emmanuel College), working on small molecule natural product synthesis.
I then worked as a lecturer in science at a college of further education, teaching
applied sciences (chemistry, life sciences and health), the physical
science components of vocational qualifications and working cross-faculty
with curriculum access and learner support teams. After spending time teaching
in the FE sector, I took a position in the chemical industry as a research scientist
for ICI, developing polymer systems for commerical refinish products. </p><p>I
returned to university to read for a D.Phil. in Organic Chemistry at the University
of Oxford (Balliol College) under the supervision of Professor Ben Davis.
My doctoral studies focused on carbohydrate synthesis and functional studies of interactions
between synthetic oligosaccharides and carbohydrate binding proteins on microarray
platforms. Upon completion of my doctorate, I moved to the Biochemistry Department
at the University of Oxford as a post-doctoral research associate working within the
Oxford Institute of Glycobiology, alongside reading part-time for a MA in Education
with the The Open University (completed in 2013). I took up my current position
as a lecturer in Chemistry with The Open University in March 2014.</p><h5>Qualifications</h5><p><strong>2013</strong> M.A.
Education (distinction) (comprising: E891, E846, SEH806) - Faculty of Education and
Language Studies, The Open University </p><p><strong>2013</strong> Postgraduate Diploma
in Professional Studies in Education (distinction) - Faculty of Education and Language
Studies, The Open University</p><p><strong>2012</strong> Postgraduate
Certificate in Professional Studies in Education (distinction) - Faculty of Education
and Language Studies, The Open University</p><p><strong>2009</strong> D.Phil.
Organic Chemistry - Department of Chemistry, University of Oxford</p><p><em>“Chemical
Mapping - Chemoenzymatic synthesis of sialylated oligosaccharides as probes of innate
immunity”</em></p><p><strong>2003</strong> Certificate
of Postgraduate Study (Organic Chemistry) - Department of Chemistry, University of
Cambridge </p><p><strong>2003</strong> City and Guilds
7307 (Further and Adult Teacher's Certificate)</p><p><strong>2001</strong> M.Sci.
Chemistry (1st) - Department of Chemistry, King’s College London, University
of London</p> |
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