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jobTitle |
Director of Research |
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research overview |
<p><strong>Non-coding RNAs (NC-RNAs). </strong>NC-RNAs represent a vast and largely
unexplored area of the human transcriptome (Crea et al. Cancer and Met Rev 2014). We
have studied the role of micro-RNAs and long non-coding RNAs (lncRNAs) in prostate
cancer progression. In particular, we have discovered and patented PCAT18, a prostate
cancer-specific lncRNA that drives metastatic progression (Crea et al. Oncotarget
2014). We are currently developing therapeutic strategies to target PCAT18. </p><p><strong>Cancer
Epigenetics. </strong>We have explored the role of epigenetic effectors as novel
biomarkers and therapeutic targets in human neoplasms. </p><p>1) We have demonstrated
that an EZH2 (Polycomb) inhibitor effectively kills prostate cancer stem cells in
vitro and in vivo. Based on this and similar results, EZH2-targeting drugs are being
investigated in clinical trials. (Crea et al. Mol Cancer 2011; Crea et al, Crit Rev
Hemat Oncol. 2012 )</p><p>2) We have identified and functionally characterized
an EZH2 genetic variant that accurately predicts prognosis in colorectal
cancer patients (Crea et al. Ann Oncol 2012; Fornaro et al. Ann Oncol 2012; Fornaro
et al BMC Cancer 2015). </p><p><strong>The epigenetic/non-coding interactome.</strong><strong> </strong>Based
on our results and on other studies, we have proposed a new paradigm of cancer progression.
We show evidence supporting the idea that an epigenetic/non-coding interactome drives
key features of cancer progression, including drug resistance and metastatic spreading
(Crea et al. Trends Mol Med 2015).</p><p><strong>Full list of Publications</strong>: https://scholar.google.co.uk/citations?user=nFGqiygAAAAJ&hl=en</p><p><strong>Internal
Collaborators: </strong>Prof. Nacho Romero (non-coding RNAs and metastatic tropism;
lncRNAs in ageing); Dr. Martin Bootman (calcium-dependent prostate cancer progression). </p> |
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hasMembership |
faculty-of-science,-technology,-engineering&mathematics |
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biography |
<p><strong>Degrees</strong></p><p>2006 MD (cum laude), University of Pisa</p><p>2010,
PhD (cum laude), Sant'Anna School of Advanced Studies</p><p><strong>Training</strong></p><p>2008-2009
Guest Scientist, Cancer Stem Cell Section, National Cancer Institute at Fredercik,
USA</p><p>2012-2015 Post Doctoral Fellow, BC Cancer Agency (Canada). </p><p><strong>Awards:</strong></p><p>2015
American Society of Clinical Oncology Merit Award</p><p>2015 Multi Institutional
Prostate Cancer Meeting \Poster Award</p><p>2014 Prostate Cancer Foundation BC post-doctoral
Award</p><p>2013 Michael Smith Foundation Trainee Award</p><p><strong>Editorial Board
Memberships:</strong></p><p>Epigenomics; The World Journal of Gastroenterology. </p> |
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holder_of |
CentralAcademicStaff |
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type |
Person |
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label |
Dr Francesco Crea |
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account |
fc3298 |
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familyName |
Crea |
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familyName |
Crea |
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Given name |
Francesco |
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Given name |
F |
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Given name |
F. |
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Given name |
F. |
| 2b3af4221b5649d1036dbad6da6de5d2 |
Given name |
Francesco |
| 2b3af4221b5649d1036dbad6da6de5d2 |
sha1sum of a personal mailbox URI name |
6f0bff230c84aaf3ce790d1276e8781c9934c3ab |
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name |
Francesco Crea |
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name |
F Crea |
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name |
F. Crea |
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name |
F. Crea |
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name |
Francesco Crea |
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page |
citations?user=nFGqiygAAAAJ&hl=en |
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title |
Dr |
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work info homepage |
fc3298 |
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Description |
<p><strong>Degrees</strong></p><p>2006 MD (cum laude), University of Pisa</p><p>2010,
PhD (cum laude), Sant'Anna School of Advanced Studies</p><p><strong>Training</strong></p><p>2008-2009
Guest Scientist, Cancer Stem Cell Section, National Cancer Institute at Fredercik,
USA</p><p>2012-2015 Post Doctoral Fellow, BC Cancer Agency (Canada). </p><p><strong>Awards:</strong></p><p>2015
American Society of Clinical Oncology Merit Award</p><p>2015 Multi Institutional
Prostate Cancer Meeting \Poster Award</p><p>2014 Prostate Cancer Foundation BC post-doctoral
Award</p><p>2013 Michael Smith Foundation Trainee Award</p><p><strong>Editorial Board
Memberships:</strong></p><p>Epigenomics; The World Journal of Gastroenterology. </p> |
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