| 09cfc1730641c06909a5138c8b166e8e |
jobTitle |
Senior Lecturer |
| 09cfc1730641c06909a5138c8b166e8e |
research overview |
<p><strong>Development</strong>of novel methods for the preparation of modified oligonucleotides
(DNA and RNA);<strong>Application</strong>of the synthetic oligonucleotides in a wide
variety of biological studies, particularly in DNA damage and repair.</p><p><u>Chemical
synthesis and biochemical applications of base-modified DNA</u><br />We have been
developing new methods for preparation of base-modified oligomers and using these
modified oligomers for biological studies, in particular for DNA repair studies. A
review was written to offer our insights into this type of work (see Xu, 2002) and
recently a novel method was published for site-specific modification of purines in
DNA (see Narukulla, Nucleic Acids Res., 2005 and Magnetic Resonance In Chemistry,
2008, Zhang, Magnetic Resonance In Chemistry, 2013 and 2016). <br /><br /><u>Photoactivation
of UVA-sensitive DNA as a novel cancer therapy</u><br />We have developed various
methods for chemical synthesis of DNA containing thiobase (4-thiothymine and 6-thioguanine)
at the predetermined positions. The thiobases are sensitive to UVA light (the UV light
with the wavelength over 320 nm). Our recent exploration of these thiobase DNA resulted
in exciting findings that thiopurines can be readily oxidized to produce harmful radicals
which cause damages to DNA and proteins (see O'Donovan, Science, 2005;
Zhang, DNA repair, 2007; Ren, NAR and Photochem and photobiology, 2010,
Moore, PLoS one 2017) and that the cells containing thiothymine are highly susceptible
to destruction upon UVA light (See Massey, Current Biology, 2001 and DNA repair, 2002
, Harada, JPC, 2007, Reelfs, MCT, 2007, Harada, JPCL, 2010, Pridgeon, 2011 and Gemenetzidis,
2013). These findings present a novel approach for targeting cancer cells with minimal
damage to normal cells. We further exploit the approach for cancer studies (see Xu,
BMCL, 2004, Zhang 2015, Chemical Letters, 2015, Ge, Progress in Chemistry 2016
and Zhang, RSC Advances 2016). Recent work with Prof. Suzuki on thioguanine analogues
offers new insights to their photochemistry and potential applications (Miyata, Photomedicine
and Photobiol., 2018; Photochem. Photobiol., 2018; J. Phys. Chem. B, 2018; Photochem&
Photobiol. Sciences, 2018).</p><p> </p> |
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hasMembership |
faculty-of-science,-technology,-engineering&mathematics |
| 09cfc1730641c06909a5138c8b166e8e |
biography |
<p><span><span><span>Senior Lecturer in School of Life, Health and Chemical Sciences.</span></span></span></p><p> </p><p><span><span><span>My
research is in the area of chemistry of nucleic acids (DNA) and its applications to
biological and medicinal sciences.</span></span></span></p><p> </p> |
| 09cfc1730641c06909a5138c8b166e8e |
holder_of |
CentralAcademicStaff |
| 09cfc1730641c06909a5138c8b166e8e |
type |
Person |
| 09cfc1730641c06909a5138c8b166e8e |
label |
Dr Yao Xu |
| 09cfc1730641c06909a5138c8b166e8e |
account |
yzx2 |
| 09cfc1730641c06909a5138c8b166e8e |
familyName |
Xu |
| 09cfc1730641c06909a5138c8b166e8e |
familyName |
Yaozhong |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Yao |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Xu |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Y-Z |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Y.-Z. |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Yao-zhong |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Yao-Zhong |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Yao-Zhong. |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
Yaozhong |
| 09cfc1730641c06909a5138c8b166e8e |
Given name |
YZ |
| 09cfc1730641c06909a5138c8b166e8e |
sha1sum of a personal mailbox URI name |
30f5943fef86d8aca11b217ae8fd00ee8e23e1e5 |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Yao Xu |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Xu Yaozhong |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Y-Z Xu |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Y.-Z. Xu |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Yao-zhong Xu |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Yao-Zhong Xu |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Yao-Zhong. Xu |
| 09cfc1730641c06909a5138c8b166e8e |
name |
Yaozhong Xu |
| 09cfc1730641c06909a5138c8b166e8e |
name |
YZ Xu |
| 09cfc1730641c06909a5138c8b166e8e |
title |
Dr |
| 09cfc1730641c06909a5138c8b166e8e |
work info homepage |
yzx2 |
| 09cfc1730641c06909a5138c8b166e8e |
Description |
<p><span><span><span>Senior Lecturer in School of Life, Health and Chemical Sciences.</span></span></span></p><p> </p><p><span><span><span>My
research is in the area of chemistry of nucleic acids (DNA) and its applications to
biological and medicinal sciences.</span></span></span></p><p> </p> |
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