subject predicate object context
72758 Creator 7886d8a8c9204366c84d0d91a5a53953
72758 Creator ext-0993761fcae826a750b423b2b0d20bbb
72758 Creator ext-0f91b42e94551b8f5e3bb2dcd33b1204
72758 Creator ext-21e25129f97f1c71de8cf8cda309be01
72758 Creator ext-2593d891e04448d55154de184a41c52e
72758 Creator ext-2ce91cdf0e17122a9ac8259324f21559
72758 Creator ext-3927376153ad4804e4ec56097b422901
72758 Creator ext-45a158d881ef9351cdf3783477d60f5c
72758 Creator ext-487e7cae626ded901f1cc1a0b04d726d
72758 Creator ext-5c0cda0b0a16912ea9b7e16d5e8784d3
72758 Creator ext-64d69300bea87ab44d42f6d80e94fa43
72758 Creator ext-6b8aabbff9db0fd354d0bb9ea27e2052
72758 Creator ext-82c6a2de4212863f72d077a8f0e5d2b3
72758 Creator ext-8ebf0c3b76a5a190d2d46495dde47b28
72758 Creator ext-937b43f656c3be62ca354e925dfe7bb6
72758 Creator ext-af02dbf3bec7564588a35747a5230d6a
72758 Creator ext-af50b6fc9b0d161d9ee065995b725056
72758 Creator ext-b349f27c88809fd6004da70e2a1d1f62
72758 Creator ext-c9e134037db0fbf166b9623a374764d5
72758 Creator ext-cb88f1e0afd7b4f05a87fce3e08bb5f3
72758 Creator ext-d2583e2319ef28155805bd5449cee34d
72758 Creator ext-d3ef5d9b4d806768b04734c6628c8e21
72758 Creator ext-e9b693d060100c330830f81bc59fa0ce
72758 Date 2020-12-09
72758 Is Part Of repository
72758 Is Part Of p10974199
72758 abstract Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic glutamate actions is poorly understood. Here, we used advanced imaging methods, <i>in situ</i> and <i>in vivo</i>, to find that a classical synaptic memory mechanism, long-term potentiation (LTP), triggers withdrawal of PAPs from potentiated synapses. Optical glutamate sensors combined with patch-clamp and 3D molecular localization reveal that LTP induction thus prompts spatial retreat of astroglial glutamate transporters, boosting glutamate spillover and NMDA-receptor-mediated inter-synaptic cross-talk. The LTP-triggered PAP withdrawal involves NKCC1 transporters and the actin-controlling protein cofilin but does not depend on major Ca<sup>2+</sup> -dependent cascades in astrocytes. We have therefore uncovered a mechanism by which a memory trace at one synapse could alter signal handling by multiple neighboring connections.
72758 authorList authors
72758 status published
72758 status peerReviewed
72758 uri http://data.open.ac.uk/oro/document/1244617
72758 uri http://data.open.ac.uk/oro/document/1244626
72758 uri http://data.open.ac.uk/oro/document/1251180
72758 uri http://data.open.ac.uk/oro/document/1251181
72758 uri http://data.open.ac.uk/oro/document/1251182
72758 uri http://data.open.ac.uk/oro/document/1251183
72758 uri http://data.open.ac.uk/oro/document/1251184
72758 uri http://data.open.ac.uk/oro/document/1251185
72758 uri http://data.open.ac.uk/oro/document/1251525
72758 volume 108
72758 type AcademicArticle
72758 type Article
72758 label Henneberger, Christian; Bard, Lucie; Panatier, Aude; Reynolds, James P; Kopach, Olga; Medvedev, Nikolay I; Minge, Daniel; Herde, Michel K; Anders, Stefanie; Kraev, Igor; Heller, Janosch P; Rama, Sylvain; Zheng, Kaiyu; Jensen, Thomas P; Sanchez-Romero, Inmaculada; Jackson, Colin J; Janovjak, Harald; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Oliet, Stephane H R; Stewart, Michael G ; Nägerl, U Valentin and Rusakov, Dmitri A (2020). LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia. Neuron, 108
72758 Title LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia.
72758 in dataset oro