| 54100 |
Creator |
538c0722d7d106c7098d06ea38e69498 |
| 54100 |
Creator |
ext-62fdf0356bbe8a54fd4140a9af606e64 |
| 54100 |
Creator |
ext-76ee67091988e23d19d429fd0559cba9 |
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Creator |
ext-c8fe0152c06fd361c09f26e7d04186a5 |
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Creator |
ext-e7b77f57b01203f8859e70f203492400 |
| 54100 |
Date |
2018-03 |
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Is Part Of |
repository |
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Is Part Of |
p13993003 |
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abstract |
While acute respiratory tract infections can trigger cardiovascular events, the differential
effect of specific organisms is unknown. This is important to guide vaccine policy.<br></br>Using
national infection surveillance data linked to the Scottish Morbidity Record, we identified
adults with a first myocardial infarction or stroke from January 1, 2004 to December
31, 2014 and a record of laboratory-confirmed respiratory infection during this period.
Using self-controlled case series analysis, we generated age- and season-adjusted
incidence ratios (IRs) for myocardial infarction (n=1227) or stroke (n=762) after
infections compared with baseline time.<br></br>We found substantially increased myocardial
infarction rates in the week after <i>Streptococcus pneumoniae</i> and influenza virus
infection: adjusted IRs for days 1-3 were 5.98 (95% CI 2.47-14.4) and 9.80 (95% CI
2.37-40.5), respectively. Rates of stroke after infection were similarly high and
remained elevated to 28 days: day 1-3 adjusted IRs 12.3 (95% CI 5.48-27.7) and 7.82
(95% CI 1.07-56.9) for <i>S. pneumoniae</i> and influenza virus, respectively. Although
other respiratory viruses were associated with raised point estimates for both outcomes,
only the day 4-7 estimate for stroke reached statistical significance.<br></br>We
showed a marked cardiovascular triggering effect of <i>S. pneumoniae</i> and influenza
virus, which highlights the need for adequate pneumococcal and influenza vaccine uptake.
Further research is needed into vascular effects of noninfluenza respiratory viruses. |
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authorList |
authors |
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issue |
3 |
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status |
published |
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status |
peerReviewed |
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uri |
http://data.open.ac.uk/oro/document/645209 |
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uri |
http://data.open.ac.uk/oro/document/645210 |
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uri |
http://data.open.ac.uk/oro/document/645211 |
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uri |
http://data.open.ac.uk/oro/document/645212 |
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uri |
http://data.open.ac.uk/oro/document/645213 |
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uri |
http://data.open.ac.uk/oro/document/645214 |
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uri |
http://data.open.ac.uk/oro/document/661809 |
| 54100 |
volume |
51 |
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type |
AcademicArticle |
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type |
Article |
| 54100 |
label |
Warren-Gash, Charlotte; Blackburn, Ruth; Whitaker, Heather ; McMenamin, Jim and
Hayward, Andrew C. (2018). Laboratory-confirmed respiratory infections as triggers
for acute myocardial infarction and stroke: a self-controlled case series analysis
of national linked datasets from Scotland. European Respiratory Journal, 51(3), article
no. 1701794. |
| 54100 |
label |
Warren-Gash, Charlotte; Blackburn, Ruth; Whitaker, Heather ; McMenamin, Jim and Hayward,
Andrew C. (2018). Laboratory-confirmed respiratory infections as triggers for acute
myocardial infarction and stroke: a self-controlled case series analysis of national
linked datasets from Scotland. European Respiratory Journal, 51(3), article no. 1701794. |
| 54100 |
Title |
Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction
and stroke: a self-controlled case series analysis of national linked datasets from
Scotland |
| 54100 |
in dataset |
oro |