| 53609 |
Creator |
538c0722d7d106c7098d06ea38e69498 |
| 53609 |
Creator |
cf4025dee845929a398330b0f5873116 |
| 53609 |
Creator |
ext-2959f2e4ceacd89670a143490bf8c2e3 |
| 53609 |
Creator |
ext-0c1a8302e4af1e4aa091136ae38e3f3a |
| 53609 |
Creator |
ext-49f391cb1a4b9b4c24b332bcafc13227 |
| 53609 |
Creator |
ext-8580f2a26162fa05ab8d514f19dfd096 |
| 53609 |
Date |
2018-03-01 |
| 53609 |
Is Part Of |
repository |
| 53609 |
Is Part Of |
p14602091 |
| 53609 |
abstract |
<b>Objectives:</b> To determine the effectiveness of live attenuated influenza vaccine
(LAIV) in reducing amoxicillin prescribing in preschool children in primary care.<br></br><br></br><b>Patients
and methods:</b> We used The Health Improvement Network (THIN), a large primary care
database from the United Kingdom. We included children aged 2 to 4 years old at the
start of either the 2013/14 or the 2014/15 winter season, with at least one amoxicillin
prescription between September and May, irrespective of LAIV vaccination status. We
used the self-controlled case series method to estimate influenza vaccine effectiveness
(VE).<br></br><br></br>
<b>Results:</b> The total study sample included 33 137 children from 378 general practices
during the two winter seasons. Of these children, 43.4% with at least one amoxicillin
prescription had been vaccinated. The rate of amoxicillin prescribing was significantly
reduced during periods of influenza vaccine immunity. The associated VE for amoxicillin
prescribing was 12.8% (95% CI 6.9%, 18.3%) in 2013/14 and 14.5% (9.6%, 19.2%) in 2014/15.
Given a VE of 14.5%, we estimated that amoxicillin prescribing could have been reduced
by 5.6% if LAIV uptake in children aged 2–4 years increased to 50% in the 2014/15
winter season.<br></br><br></br><b>Conclusions:</b> Influenza vaccination of young
children may contribute to a reduction in the prescribing of amoxicillin, one of the
most commonly prescribed antibiotics in primary care. Further studies are required
to confirm the size of the effect. |
| 53609 |
authorList |
authors |
| 53609 |
issue |
3 |
| 53609 |
status |
published |
| 53609 |
status |
peerReviewed |
| 53609 |
volume |
73 |
| 53609 |
type |
AcademicArticle |
| 53609 |
type |
Article |
| 53609 |
label |
Hardelid, Pia; Ghebremichael-Weldeselassie, Yonas ; Whitaker, Heather ; Rait, Greta;
Gilbert, Ruth and Petersen, Irene (2018). Effectiveness of live attenuated influenza
vaccine in preventing amoxicillin prescribing in preschool children: a self-controlled
case series study. Journal of Antimicrobial Chemotherapy, 73(3) pp. 779–786.
|
| 53609 |
label |
Hardelid, Pia; Ghebremichael-Weldeselassie, Yonas ; Whitaker, Heather ; Rait, Greta;
Gilbert, Ruth and Petersen, Irene (2018). Effectiveness of live attenuated influenza
vaccine in preventing amoxicillin prescribing in preschool children: a self-controlled
case series study. Journal of Antimicrobial Chemotherapy, 73(3) pp. 779–786. |
| 53609 |
Publisher |
ext-daeb92daf570917684167066877da0ed |
| 53609 |
Title |
Effectiveness of live attenuated influenza vaccine in preventing amoxicillin prescribing
in preschool children: a self-controlled case series study |
| 53609 |
in dataset |
oro |