| 51779 |
Creator |
538c0722d7d106c7098d06ea38e69498 |
| 51779 |
Creator |
ext-52d7ee1839eb211e92a73cd6d39e2cf5 |
| 51779 |
Creator |
ext-1f5244d6b26f0efb4365ad58e2992869 |
| 51779 |
Creator |
ext-38b261813d47ff53d0bdf4e5c0568e22 |
| 51779 |
Creator |
ext-3be743a18dc7455175c0f0c2dc78fe61 |
| 51779 |
Creator |
ext-5c2d58851ef0908191b22bf3c55bd0b0 |
| 51779 |
Creator |
ext-9b2c5630b6dcef1442f0eed4e16f404b |
| 51779 |
Creator |
ext-a14910905f662ca9222e8ff087fb4f43 |
| 51779 |
Creator |
ext-c4cb5f8f09925144009d3aecb29a9cbd |
| 51779 |
Creator |
ext-d285a670cd892f6b00c9cc6d460d7bf9 |
| 51779 |
Creator |
ext-e30629a18022f50797541790a182a729 |
| 51779 |
Creator |
ext-e4d3b9d06079aea71b7267cd6cd62809 |
| 51779 |
Date |
2017-10-01 |
| 51779 |
Is Part Of |
repository |
| 51779 |
Is Part Of |
p17474949 |
| 51779 |
abstract |
Background<br></br> It is unclear whether the risk of bleeding from brain arteriovenous
malformations is higher during pregnancy, delivery, or puerperium. We compared occurrence
of brain arteriovenous malformation hemorrhage in women during this period with occurrence
of hemorrhage outside this period during their fertile years.<br></br> Methods<br></br>
We included all women with ruptured brain arteriovenous malformations (16-41 years)
from a retrospective database of patients with brain arteriovenous malformations in
four Dutch university hospitals (n = 95) and from the population-based Scottish Audit
of Intracranial Vascular Malformations (n = 44). We estimated the relative rate of
brain arteriovenous malformation rupture (before any treatment) during exposed time
(pregnancy, delivery, puerperium) versus non-exposed time during fertile years, using
the case-crossover design as primary analysis, and the self-controlled case-series
design as secondary analysis. <br></br>Results<br></br> In 17 of 95 Dutch women and
in 3 of 44 Scottish women, hemorrhages occurred while pregnant; none occurred during
delivery or puerperium. In Dutch women, the relative rate of brain arteriovenous malformation
rupture during pregnancy, delivery, or puerperium was 6.8 (95% confidence interval
3.6-13) according to the case-crossover method and 7.1 (95% confidence interval 3.4-13)
using the self-controlled case-series method. In Scottish women, the relative rate
was 1.3 (95% confidence interval 0.39-4.1) using the case-crossover method and 1.7
(95% confidence interval 0.0-4.4) according to the self-controlled case-series method.
Because of limited overlap of confidence intervals, we refrained from pooling the
cohorts. <br></br>Conclusions<br></br> Case-crossover and self-controlled case series
analyses reveal an increase in relative rate of brain arteriovenous malformation rupture
during pregnancy in the Dutch cohort but not in the Scottish cohort. Since point estimates
varied between both cohorts and numbers are relatively small, the clinical implications
of our findings are uncertain. |
| 51779 |
authorList |
authors |
| 51779 |
issue |
7 |
| 51779 |
status |
published |
| 51779 |
status |
peerReviewed |
| 51779 |
uri |
http://data.open.ac.uk/oro/document/646193 |
| 51779 |
uri |
http://data.open.ac.uk/oro/document/646194 |
| 51779 |
uri |
http://data.open.ac.uk/oro/document/646195 |
| 51779 |
uri |
http://data.open.ac.uk/oro/document/646196 |
| 51779 |
uri |
http://data.open.ac.uk/oro/document/646197 |
| 51779 |
uri |
http://data.open.ac.uk/oro/document/646198 |
| 51779 |
uri |
http://data.open.ac.uk/oro/document/661113 |
| 51779 |
volume |
12 |
| 51779 |
type |
AcademicArticle |
| 51779 |
type |
Article |
| 51779 |
label |
van Beijnum, Janneke; Wilkinson, Tim; Whitaker, Heather J ; van der Bom, Johanna G;
Algra, Ale; Vandertop, W Peter; van den Berg, René; Brouwer, Patrick A; Rinkel, Gabriël
Je; Kappelle, L Jaap; Al-Shahi Salman, Rustam and Klijn, Catharina Jm (2017). Relative
risk of hemorrhage during pregnancy in patients with brain arteriovenous malformations.
International Journal of Stroke, 12(7) pp. 741–747. |
| 51779 |
label |
van Beijnum, Janneke; Wilkinson, Tim; Whitaker, Heather J ; van der Bom, Johanna
G; Algra, Ale; Vandertop, W Peter; van den Berg, René; Brouwer, Patrick A; Rinkel,
Gabriël Je; Kappelle, L Jaap; Al-Shahi Salman, Rustam and Klijn, Catharina Jm (2017).
Relative risk of hemorrhage during pregnancy in patients with brain arteriovenous
malformations. International Journal of Stroke, 12(7) pp. 741–747. |
| 51779 |
Title |
Relative risk of hemorrhage during pregnancy in patients with brain arteriovenous
malformations |
| 51779 |
in dataset |
oro |