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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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| 43947 |
Creator |
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Creator |
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Creator |
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Creator |
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Creator |
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Date |
2015 |
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Date |
2015-08-03 |
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Is Part Of |
repository |
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Is Part Of |
p15461726 |
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abstract |
Hippocampal pathology is likely to contribute to cognitive disability in Down syndrome,
yet the neural network basis of this pathology and its contributions to different
facets of cognitive impairment remain unclear. Here we report dysfunctional connectivity
between dentate gyrus and CA3 networks in the transchromosomic Tc1 mouse model of
Down syndrome, demonstrating that ultrastructural abnormalities and impaired short-term
plasticity at dentate gyrus–CA3 excitatory synapses culminate in impaired coding of
new spatial information in CA3 and CA1 and disrupted behavior in vivo. These results
highlight the vulnerability of dentate gyrus–CA3 networks to aberrant human chromosome
21 gene expression and delineate hippocampal circuit abnormalities likely to contribute
to distinct cognitive phenotypes in Down syndrome. |
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authorList |
authors |
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status |
peerReviewed |
| 43947 |
volume |
18 |
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type |
AcademicArticle |
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type |
Article |
| 43947 |
label |
Witton, Jonathan; Padmashri, Ragunathan; Zinyuk, Larissa E.; Popov, Victor I. ; Kraev,
Igor ; Line, Samantha J.; Jensen, Thomas P.; Tedoldi, Angelo; Cummings, Damian M.;
Tybulewicz, Victor L. J.; Fisher, Elizabeth M. C.; Bannerman, David M.; Randall, Andrew
D.; Brown, Jonathan T.; Edwards, Frances A.; Rusakov, Dmitri A.; Stewart, Michael
G. and Jones, Matt W. (2015). Hippocampal circuit dysfunction in the Tc1 mouse model
of Down syndrome. Nature Neuroscience, 18 pp. 1291–1298. |
| 43947 |
label |
Witton, Jonathan; Padmashri, Ragunathan; Zinyuk, Larissa E.; Popov, Victor I. ;
Kraev, Igor ; Line, Samantha J.; Jensen, Thomas P.; Tedoldi, Angelo; Cummings, Damian
M.; Tybulewicz, Victor L. J.; Fisher, Elizabeth M. C.; Bannerman, David M.; Randall,
Andrew D.; Brown, Jonathan T.; Edwards, Frances A.; Rusakov, Dmitri A.; Stewart, Michael
G. and Jones, Matt W. (2015). Hippocampal circuit dysfunction in the Tc1 mouse model
of Down syndrome. Nature Neuroscience, 18 pp. 1291–1298. |
| 43947 |
Title |
Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome |
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in dataset |
oro |