| 43782 |
Creator |
4de854f542f9d6b1f31bc23c95154aa0 |
| 43782 |
Creator |
7886d8a8c9204366c84d0d91a5a53953 |
| 43782 |
Creator |
4c406793674fe444c95e7d252e76a124 |
| 43782 |
Creator |
0d0a2bf7401628bfe2466124b15edfd9 |
| 43782 |
Creator |
ext-1fb08962d2dc8afcefd30851b68a61fd |
| 43782 |
Creator |
ext-5ba5fb1be735f523347581b9679eb2a5 |
| 43782 |
Date |
2015-09-10 |
| 43782 |
Is Part Of |
p03064522 |
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Is Part Of |
repository |
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abstract |
A central component of Attention-Deficit Hyperactivity Disorder (ADHD) is increased
distractibility, which is linked to the superior colliculus (SC) in a range of species,
including humans. Furthermore, there is now mounting evidence of altered collicular
functioning in ADHD and it is proposed that a hyper-responsive SC could mediate the
main symptoms of ADHD, including distractibility. In the present study we have provided
a systematic characterization of the SC in the most commonly used and well-validated
animal model of ADHD, the spontaneously hypertensive rat (SHR). We examined collicular-dependent
orienting behavior, local field potential (LFP) and multiunit responses to visual
stimuli in the anesthetized rat and morphological measures in the SHR in comparison
to the Wistar Kyoto (WKY) and Wistar (WIS). We found that SHRs remain responsive to
a repeated visual stimulus for more presentations than control strains and have a
longer response duration. In addition, LFP and multiunit activity within the visually
responsive superficial layers of the SC showed the SHR to have a hyper-responsive
SC relative to control strains, which could not be explained by altered functioning
of the retinocollicular pathway. Finally, examination of collicular volume, neuron
and glia densities and glia:neuron ratio revealed that the SHR had a reduced ratio
relative to the WKY which could explain the increased responsiveness. In conclusion,
this study demonstrates strain-specific changes in the functioning and structure of
the SC in the SHR, providing convergent evidence that the SC might be dysfunctional
in ADHD. |
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authorList |
authors |
| 43782 |
status |
peerReviewed |
| 43782 |
uri |
http://data.open.ac.uk/oro/document/883549 |
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uri |
http://data.open.ac.uk/oro/document/883562 |
| 43782 |
uri |
http://data.open.ac.uk/oro/document/883563 |
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uri |
http://data.open.ac.uk/oro/document/883564 |
| 43782 |
uri |
http://data.open.ac.uk/oro/document/883565 |
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uri |
http://data.open.ac.uk/oro/document/883566 |
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uri |
http://data.open.ac.uk/oro/document/884105 |
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volume |
303 |
| 43782 |
type |
AcademicArticle |
| 43782 |
type |
Article |
| 43782 |
label |
Brace, L. R. ; Kraev, I. ; Rostron, C. L. ; Stewart, M. G. ; Overton, P. G. and
Dommett, E. J. (2015). Altered visual processing in a rodent model of Attention-Deficit
Hyperactivity Disorder. Neuroscience, 303 pp. 364–377. |
| 43782 |
label |
Brace, L. R. ; Kraev, I. ; Rostron, C. L. ; Stewart, M. G. ; Overton, P. G. and Dommett,
E. J. (2015). Altered visual processing in a rodent model of Attention-Deficit Hyperactivity
Disorder. Neuroscience, 303 pp. 364–377. |
| 43782 |
Title |
Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder |
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in dataset |
oro |