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Creator |
4de854f542f9d6b1f31bc23c95154aa0 |
| 39404 |
Creator |
7886d8a8c9204366c84d0d91a5a53953 |
| 39404 |
Creator |
0db3bf16f8a5801f2fc91f3b6d2c5978 |
| 39404 |
Creator |
ext-c48b4cdcf2536b41992c906e58d2549c |
| 39404 |
Creator |
ext-09843cc9acd235676b132220e1da5789 |
| 39404 |
Creator |
ext-0f18bd671afb7ec2f8ef31c2070fd25d |
| 39404 |
Creator |
ext-0b4fb5e78b28ffc241469e75a9592a74 |
| 39404 |
Creator |
ext-2064ebbbfc3604a7f2d778a2e5219ac4 |
| 39404 |
Creator |
ext-616f2e31964d2dd8b2488ee8d30b42a8 |
| 39404 |
Creator |
ext-6b3a61dc7d26a39094d5ed5e79f52edb |
| 39404 |
Creator |
ext-9a4c9e39097b4514e72a82926eedcf2c |
| 39404 |
Creator |
ext-d669b59b8a09ce7431f0ccaf7942f60f |
| 39404 |
Creator |
ext-f0b6120ef92ab54853a1236395116cbc |
| 39404 |
Date |
2014-02-03 |
| 39404 |
Is Part Of |
p19326203 |
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Is Part Of |
repository |
| 39404 |
abstract |
The stratum lacunosum moleculare (SLM) is the connection hub between entorhinal cortex
and hippocampus, two brain regions that are most vulnerable in Alzheimer’s disease.
We recently identified a specific synaptic deficit of Nectin-3 in transgenic models
for tauopathy. Here we defined cognitive impairment and electrophysiological problems
in the SLM of Tau.P301L mice, which corroborated the structural defects in synapses
and dendritic spines. Reduced diffusion of DiI from the ERC to the hippocampus indicated
defective myelinated axonal pathways. Ultrastructurally, myelinated axons in the temporoammonic
pathway (TA) that connects ERC to CA1 were damaged in Tau.P301L mice at young age.
Unexpectedly, the myelin defects were even more severe in bigenic biGT mice that co-express
GSK3β with Tau.P301L in neurons. Combined, our data demonstrate that neuronal expression
of protein Tau profoundly affected the functional and structural organization of the
entorhinal-hippocampal complex, in particular synapses and myelinated axons in the
SLM. White matter pathology deserves further attention in patients suffering from
tauopathy and Alzheimer’s disease. |
| 39404 |
authorList |
authors |
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status |
peerReviewed |
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uri |
http://data.open.ac.uk/oro/document/216491 |
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uri |
http://data.open.ac.uk/oro/document/216523 |
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uri |
http://data.open.ac.uk/oro/document/216524 |
| 39404 |
uri |
http://data.open.ac.uk/oro/document/216525 |
| 39404 |
uri |
http://data.open.ac.uk/oro/document/216526 |
| 39404 |
uri |
http://data.open.ac.uk/oro/document/216527 |
| 39404 |
uri |
http://data.open.ac.uk/oro/document/216581 |
| 39404 |
type |
AcademicArticle |
| 39404 |
type |
Article |
| 39404 |
label |
Maurin, Hervé; Chong, Seon-Ah; Kraev, Igor ; Davies, Heather ; Kremer, Anna; Seymour,
Claire Marie; Lechat, Benoit; Jaworski, Tomasz; Borghgraef, Peter; Devijver, Herman;
Callewaert, Geert; Stewart, Michael G. and Van Leuven, Fred (2014). Early structural
and functional defects in synapses and myelinated axons in stratum lacunosum moleculare
in two preclinical models for tauopaty. PLoS ONE |
| 39404 |
label |
Maurin, Hervé; Chong, Seon-Ah; Kraev, Igor ; Davies, Heather ; Kremer, Anna; Seymour,
Claire Marie; Lechat, Benoit; Jaworski, Tomasz; Borghgraef, Peter; Devijver, Herman;
Callewaert, Geert; Stewart, Michael G. and Van Leuven, Fred (2014). Early structural
and functional defects in synapses and myelinated axons in stratum lacunosum moleculare
in two preclinical models for tauopaty. PLoS ONE |
| 39404 |
Title |
Early structural and functional defects in synapses and myelinated axons in stratum
lacunosum moleculare in two preclinical models for tauopaty |
| 39404 |
in dataset |
oro |