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Creator |
4de854f542f9d6b1f31bc23c95154aa0 |
| 39343 |
Creator |
7886d8a8c9204366c84d0d91a5a53953 |
| 39343 |
Creator |
0db3bf16f8a5801f2fc91f3b6d2c5978 |
| 39343 |
Creator |
a49cd65f994f44f9567f65920769d193 |
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Creator |
cb7684be22723b3c4fd296568682adef |
| 39343 |
Creator |
ext-0b3304176f592b36ee9d2ed8cbf43065 |
| 39343 |
Creator |
ext-8c2a82b6b780f11d4e5ed303c9afc5f2 |
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Creator |
ext-c8e37f7ac17aea1af5b0d95c49327684 |
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Date |
2014 |
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Is Part Of |
repository |
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Is Part Of |
p18632661 |
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abstract |
The formation of multiple spine boutons (MSBs) has been associated with cognitive
abilities including hippocampal-dependent associative learning and memory. Data obtained
from cultured hippocampal slices suggest that the long-term maintenance of synaptic
plasticity requires the formation of new synaptic contacts on pre-existing synapses.
This postulate however, has never been tested in the awake, freely moving animals.
In the current study, we induced long-term potentiation (LTP) in the dentate gyrus
(DG) of awake adult rats and performed 3-D reconstructions of electron micrographs
from thin sections of both axonal boutons and dendritic spines, 24 h post-induction.
The specificity of the observed changes was demonstrated by comparison with animals
in which long-term depression (LTD) had been induced, or with animals in which LTP
was blocked by an N-methyl-D-aspartate (NMDA) antagonist. Our data demonstrate that
whilst the number of boutons remains unchanged, there is a marked increase in the
number of synapses per bouton 24 h after the induction of LTP. Further, we demonstrate
that this increase is specific to mushroom spines and not attributable to their division.
The present investigation thus fills the gap existing between behavioural and in vitro
studies on the role of MSB formation in synaptic plasticity and cognitive abilities. |
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authorList |
authors |
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issue |
1 |
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status |
peerReviewed |
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volume |
219 |
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type |
AcademicArticle |
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type |
Article |
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label |
Medvedev, Ni. I. ; Dallérac, G.; Popov, V. I. ; Rodriguez Arellano, J. J.; Davies,
H. A. ; Kraev, I. V. ; Doyère, V. and Stewart, M. G. (2014). Multiple spine boutons
are formed after long-lasting LTP in the awake rat. Brain Structure & Function, 219(1)
pp. 407–414. |
| 39343 |
label |
Medvedev, Ni. I. ; Dallérac, G.; Popov, V. I. ; Rodriguez Arellano, J. J.; Davies,
H. A. ; Kraev, I. V. ; Doyère, V. and Stewart, M. G. (2014). Multiple spine boutons
are formed after long-lasting LTP in the awake rat. Brain Structure & Function, 219(1)
pp. 407–414. |
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sameAs |
s00429-012-0488-0 |
| 39343 |
Title |
Multiple spine boutons are formed after long-lasting LTP in the awake rat |
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in dataset |
oro |