| 37977 |
Creator |
8c9e8ffbe377cfe0a0901acca966ce04 |
| 37977 |
Creator |
abf91f4d682b4516f53c9e0fab6ea3c2 |
| 37977 |
Creator |
0db3bf16f8a5801f2fc91f3b6d2c5978 |
| 37977 |
Creator |
2f00cd67da9531d3b038df995e295665 |
| 37977 |
Creator |
3911091e0152e7d6566dc2b0d03a49b9 |
| 37977 |
Creator |
8a831f703fd01b4e732f117d372e7fcc |
| 37977 |
Date |
2013-10-01 |
| 37977 |
Is Part Of |
repository |
| 37977 |
Is Part Of |
p18785905 |
| 37977 |
abstract |
A new combination of tissue engineering techniques provides a simple and effective
method for building aligned cellular biomaterials. Self-alignment of Schwann cells
within a tethered type-1 collagen matrix, followed by removal of interstitial fluid
produces a stable tissue-like biomaterial that recreates the aligned cellular and
extracellular matrix architecture associated with nerve grafts. Sheets of this engineered
neural tissue supported and directed neuronal growth in a co-culture model, and initial
in vivo tests showed that a device containing rods of rolled-up sheets could support
neuronal growth during rat sciatic nerve repair (5 mm gap). Further testing of this
device for repair of a critical-sized 15 mm gap showed that, at 8 weeks, engineered
neural tissue had supported robust neuronal regeneration across the gap. This is,
therefore, a useful new approach for generating anisotropic engineered tissues, and
it can be used with Schwann cells to fabricate artificial neural tissue for peripheral
nerve repair. |
| 37977 |
authorList |
authors |
| 37977 |
issue |
30 |
| 37977 |
status |
peerReviewed |
| 37977 |
uri |
http://data.open.ac.uk/oro/document/198663 |
| 37977 |
uri |
http://data.open.ac.uk/oro/document/198664 |
| 37977 |
uri |
http://data.open.ac.uk/oro/document/198665 |
| 37977 |
uri |
http://data.open.ac.uk/oro/document/198666 |
| 37977 |
uri |
http://data.open.ac.uk/oro/document/198667 |
| 37977 |
uri |
http://data.open.ac.uk/oro/document/198668 |
| 37977 |
uri |
http://data.open.ac.uk/oro/document/198669 |
| 37977 |
volume |
34 |
| 37977 |
type |
AcademicArticle |
| 37977 |
type |
Article |
| 37977 |
label |
Georgiou, Melanie ; Bunting, Stephen C. J. ; Davies, Heather A. ; Loughlin, Alison
J. ; Golding, Jonathan P. and Phillips, James B. (2013). Engineered neural tissue
for peripheral nerve repair. Biomaterials, 34(30) pp. 7335–7343. |
| 37977 |
label |
Georgiou, Melanie ; Bunting, Stephen C. J. ; Davies, Heather A. ; Loughlin, Alison
J. ; Golding, Jonathan P. and Phillips, James B. (2013). Engineered neural tissue
for peripheral nerve repair. Biomaterials, 34(30) pp. 7335–7343. |
| 37977 |
Title |
Engineered neural tissue for peripheral nerve repair |
| 37977 |
in dataset |
oro |