| 27025 |
Creator |
8c9e8ffbe377cfe0a0901acca966ce04 |
| 27025 |
Creator |
ext-2f93abf767772e95895b8a0cf5eb8a82 |
| 27025 |
Creator |
ext-cc04a35658077b2229ce9e282afc0621 |
| 27025 |
Creator |
ext-06d21ca9c1e6436b3371398e4671f9c0 |
| 27025 |
Creator |
ext-2230fe9373e11ce0edf0acfa78369196 |
| 27025 |
Creator |
ext-9256c9cd2e6fcdb25cd3df7ca66c6a40 |
| 27025 |
Creator |
ext-9e5b1733f8fac036e748016a3388c243 |
| 27025 |
Date |
1996-12 |
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Is Part Of |
repository |
| 27025 |
Is Part Of |
p00223069 |
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abstract |
The expression of tissue-type plasminogen activator (t-PA) and a number of metalloproteases
as well as plasminogen activator inhibitor-1 (PAI-I) and tissue inhibitor of metalloproteases-1
(TIMP-1) was analyzed in the central nervous system (CNS) of normal control and multiple
sclerosis (MS) cases by immunohistopathology. The expression of t-PA was detectable
only in the blood vessel matrix in control white matter, but positive infiltrating
mononuclear cells were also observed in MS white matter and primary lesions. In active
plaques this pattern converted to strong positivity of foamy macrophages in areas
of demyelination, declining in chronic lesions. In general PAI-1 expression paralleled
that of t-PA. Gelatinase A and B were detected predominantly in astrocytes and microglia
throughout normal control white matter, with additional positive mononuclear cells
in perivascular cuffs in MS white matter. In the demyelinating lesion there is widespread
prominent expression of gelatinase B in reactive astrocytes and macrophages, which
persists in astrocytes in the chronic lesion. TIMP-1 was also present in the vessel
matrix and in lesional macrophages. These observations on the coexpression of enzymes
and inhibitors of the matrix degrading cascade in CNS tissue pinpoint t-PA, a -limiting
enzyme, and gelatinase B as therapeutic targets in MS. |
| 27025 |
authorList |
authors |
| 27025 |
issue |
12 |
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status |
peerReviewed |
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volume |
55 |
| 27025 |
type |
AcademicArticle |
| 27025 |
type |
Article |
| 27025 |
label |
Cuzner, M. L.; Gveric, D.; Strand, C.; Loughlin, Jane ; Paemen, L.; Opdenakker,
G. and Newcombe, J. (1996). The expression of tissue-type plasminogen activator,
matrix metalloproteases and endogenous inhibitors in the central nervous system in
multiple sclerosis: comparison of stages in lesion evolution. Journal of Neuropathology
and Experimental Neurology, 55(12) pp. 1194–1204. |
| 27025 |
label |
Cuzner, M. L.; Gveric, D.; Strand, C.; Loughlin, Jane ; Paemen, L.; Opdenakker, G.
and Newcombe, J. (1996). The expression of tissue-type plasminogen activator, matrix
metalloproteases and endogenous inhibitors in the central nervous system in multiple
sclerosis: comparison of stages in lesion evolution. Journal of Neuropathology and
Experimental Neurology, 55(12) pp. 1194–1204. |
| 27025 |
Title |
The expression of tissue-type plasminogen activator, matrix metalloproteases and endogenous
inhibitors in the central nervous system in multiple sclerosis: comparison of stages
in lesion evolution |
| 27025 |
in dataset |
oro |