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Creator |
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Creator |
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Creator |
ext-98d68f4cec4e55e0b4b3ecb383a1845d |
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Creator |
ext-2bdc2db59d14fe556fa4dd2273cd078d |
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Creator |
ext-d60c5f331dbc14edd9caa8f7d609567d |
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Creator |
ext-7765010057f3364f4dc1e5c9b60e5eb6 |
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Creator |
ext-c61147ac66f6533e2441c4e0fc0d78a4 |
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Creator |
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Creator |
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Creator |
ext-70e72b5d9c3666c5ef0a1ccf16ad72a5 |
| 18206 |
Date |
2005-08 |
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Is Part Of |
repository |
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Is Part Of |
p13652036 |
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abstract |
<b>Background:</b>A 15-fold increased risk of gastrointestinal bleeding has been reported
with concurrent use of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory
drugs. Recent guidance cautions against concurrent prescription, particularly in older
people.<br></br><br></br><b> Aim:</b> To quantify the risk of gastrointestinal bleeding
associated with current exposure to non-steroidal anti-inflammatory drugs, selective
serotonin reuptake inhibitors, and both drugs concurrently.<br></br><br></br><b> Methods:</b>
We conducted a case-control analysis of 11 261 cases with upper gastrointestinal bleeding
and 53 156 controls matched by gender, age and general practice from computerized
primary care data. We coupled this with self-controlled case series analysis. <br></br><br></br><b>Results:</b>
Both drugs were associated with a twofold increased risk of gastrointestinal bleeding
(odds ratio =2.38, 95% confidence interval 2.08-2.72 for selective serotonin reuptake
inhibitors and odds ratio = 2.15, 95% confidence interval 2.02-2.28 for non-steroidal
anti-inflammatory drugs). This increased risk was marginally higher for concurrent
prescription (odds ratio = 2.93, 95%confidence interval 2.25-3.82). The self-controlled
analysis showed a greater incidence rate ratio for gastrointestinal bleeding with
non-steroidal anti-inflammatory drugs (2.71, 95% confidence interval 2.51-2.91) and
lower incidence rate ratio with selective serotonin reuptake inhibitors (1.71, 95%
confidence interval 1.48-1.98). The incidence rate ratio when both drugs were combined
was 3.25, 95% confidence interval 1.95-5.42. Estimates were similar after restricting
to people over 80 years of age. Increased risk of gastrointestinal bleeding was not
specifically related to class of non-steroidal anti-inflammatory drugs and was similar
when we looked at tricyclic anti-depressants. <br></br><br></br><b>Conclusions:</b>
Our study suggests that the risk of gastrointestinal bleeding is not substantially
increased when non-steroidal anti-inflammatory drugs and selective serotonin reuptake
inhibitors are prescribed together, compared with their use alone. |
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authorList |
authors |
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issue |
3 |
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status |
peerReviewed |
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volume |
22 |
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type |
AcademicArticle |
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type |
Article |
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label |
Tata, L. J.; Fortun, P. J.; Hubbard, R. B.; Smeeth, L.; Hawkey, C. J.; Smith, C. J.
P.; Whitaker, H. J. ; Farrington, C. P. ; Card, T. R. and West, J. (2005). Does concurrent
prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory
drugs substantially increase the risk of upper gastrointestinal bleeding? Alimentary
Pharmacology & Therapeutics, 22(3) pp. 175–181. |
| 18206 |
label |
Tata, L. J.; Fortun, P. J.; Hubbard, R. B.; Smeeth, L.; Hawkey, C. J.; Smith, C.
J. P.; Whitaker, H. J. ; Farrington, C. P. ; Card, T. R. and West, J. (2005). Does
concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal
anti-inflammatory drugs substantially increase the risk of upper gastrointestinal
bleeding? Alimentary Pharmacology & Therapeutics, 22(3) pp. 175–181. |
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Title |
Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal
anti-inflammatory drugs substantially increase the risk of upper gastrointestinal
bleeding? |
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in dataset |
oro |