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s322 has-courseware 170359
170359 url holdingsInfo?bibId=170359
170359 P1007 produced by Jack Koumi; contributor David Phillips.
170359 isAbout model
170359 isAbout microscopy
170359 isAbout %60cleft'
170359 isAbout bacterial cell walls
170359 isAbout computer animations
170359 isAbout lysozyme structure
170359 Contributor 3fadbf8f4d96564844175155a5a8fa47
170359 Contributor f10be97f9070b3ce180b69e5cfaca8e8
170359 Table Of Contents The programme starts by summarising TV.3 "The Structure of Lysozyme" with a sequence in which various rotating models of the lysozyme molecule are superimposed to highlight some distinctive features, ending with the "cleft" which is involved in the action. Professor David Phillips of Oxford University explains that to describe the action of lysozyme, it is relevant to consider why the chain molecule takes up its particular globular shape. The model used in TV3, of the chain of 129 amino-acid residues, changes colour to distinguish between the hydrophilic and hydrophobic side-chains. A computer animated film builds up the molecule to show that hydrophilic side-chains remain on the surface, whereas hydrophobic side-chains are folded into the interior. This is illustrated again on a "hydrophilic/hydrophobic" model of the molecule. The action of lysozyme on bacterial cell walls is described using a microscopy film, three video animation sequences describing the polysaccharide structure of a cell wall, a model of the active site attached to a six-ring segment of a polysaccharide, two separate models of this hexasaccharide, an animated film of the action and, finally, the earlier "hydrophilic/hydrophobic" model of lysozyme. The programme ends with various superimpositions of the rotating globular-shaped models.
170359 locator holdingsInfo?bibId=170359
170359 type Collection
170359 label The action of lyzosyme
170359 Description This is the second of two programmes on the structure and action of lysozyme. The programme describes the action of lysozyme on bacterial cell walls.
170359 Publisher 07f21de77e80d6bd38c3be6db6cb323d
170359 Title The action of lyzosyme